2-[N-(4-Aminophenyl)amino]-4,6-dimethylpyrimidine

Base Information

• Chemical Name: 2-[N-(4-Aminophenyl)amino]-4,6-dimethylpyrimidine
• CAS No.: 81261-93-0
• Molecular Formula: C12H14N4
• Molecular Weight: 214.27
• Hs Code.: 2933599090
• European Community (EC) Number: 674-409-3
• Mol file: 81261-93-0.mol

Synonyms:81261-93-0;2-[N-(4-Aminophenyl)amino]-4,6-dimethylpyrimidine;N1-(4,6-Dimethylpyrimidin-2-yl)benzene-1,4-diamine;N-(4,6-Dimethylpyrimidin-2-yl)benzene-1,4-diamine;n-(4-aminophenyl)-4,6-dimethyl-2-pyrimidinamine;4-N-(4,6-dimethylpyrimidin-2-yl)benzene-1,4-diamine;MFCD00202977;GRY;1,4-Benzenediamine,N1-(4,6-dimethyl-2-pyrimidinyl)-;1-N-(4,6-dimethylpyrimidin-2-yl)benzene-1,4-diamine;Peakdale1_000018;SCHEMBL4816252;HMS518A18;AMY41485;AKOS002674902;PS-5746;SB57859;CS-0317153;FT-0641816;A840078;SR-01000385173;SR-01000385173-1;2-[N-(4-aminophenyl)amino]-4,6-dimethylpyrimidine, AldrichCPR

Chemical Property of 2-[N-(4-Aminophenyl)amino]-4,6-dimethylpyrimidine

Chemical Property:

• Vapor Pressure: 1.35E-07mmHg at 25°C
• Melting Point: 192-195 ºC
• Refractive Index: 1.665
• Boiling Point: 429.9 °C at 760 mmHg
• Flash Point: 213.8 °C
• PSA: 63.83000
• Density: 1.212 g/cm³
• LogP: 3.07340
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 214.121846464
• Heavy Atom Count: 16
• Complexity: 203

Purity/Quality:

97% ^*data from raw suppliers

2-[N-(4-Aminophenyl)amino]-4,6-dimethylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 36/37/38-36-34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)NC2=CC=C(C=C2)N)C
• Uses: 2-[N-(4-Aminophenyl)amino]-4,6-dimethylpyrimidine can be used in the treatment of proliferative diseases.

Technology Process of 2-[N-(4-Aminophenyl)amino]-4,6-dimethylpyrimidine

There total 4 articles about 2-[N-(4-Aminophenyl)amino]-4,6-dimethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sulfadimesine (57-68-1) → 2-Amino-4,6-dimethylpyrimidine (767-15-7,184433-59-8) + N-(4,6-dimethyl-2-pyrimidine)-1,4-phenylenediamine (81261-93-0) + N-(4,6-dimethyl-2-pyrimidine)-4-N-(benzenesulfonamide)benzenesulfonamide + N-(4,6-dimethyl-2-pyrimidine)-4-N-(4,6-dimethylpyrimidine)benzenesulfonamide + 2-amino-5-hydroxypyrimidine-4,6(1H,3H)-dione + 5-Hydroxysulphadimidine (51395-19-8) + 4-aminobenzene sulfonic acid (121-57-3,856062-06-1)

Guidance literature:

With ferrous(II) sulfate heptahydrate; zinc(II) sulfate heptahydrate; potassium dihydrogenphosphate; magnesium sulfate heptahydrate; copper(II) choride dihydrate; calcium(II) chloride dihydrate; manganese(II) chloride tetrahydrate; cobalt(II) chloride hexahydrate; sodium molybdate dihydrate; sodium acetate; boric acid; ammonium chloride; potassium iodide; corn starch; In water; at 20 ℃; Microbiological reaction;

DOI:10.1016/j.cclet.2019.08.031

Reference yield:

sulfadimesine (57-68-1) → 2-Amino-4,6-dimethylpyrimidine (767-15-7,184433-59-8) + N-(4,6-dimethyl-2-pyrimidine)-1,4-phenylenediamine (81261-93-0) + carbon dioxide (124-38-9,18923-20-1)

Guidance literature:

With graphitic carbon nitride; dihydrogen peroxide; In water; for 1.5h; pH=6.9; Reagent/catalyst; Kinetics; Irradiation;

DOI:10.1039/c5ra21895k

Reference yield:

sulfadimesine (57-68-1) → N-(4,6-dimethyl-2-pyrimidine)-1,4-phenylenediamine (81261-93-0) + C12H12N4O2 + 2,5-diamino-1,4-benzenediol (10325-89-0)

Guidance literature:

With dihydrogen peroxide; iron; In water; at 20 ℃; Electrochemical reaction;

DOI:10.1021/jf904066a

upstream raw materials:

2-chloro-4,6-dimethylpyrimidine

4-nitro-aniline

sulfadimesine