2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

Base Information

Chemical Name:2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol
CAS No.:1450620-72-0
Molecular Formula:C₂₁H₂₁ClF₃N₃O₄S
Molecular Weight:503.93
Hs Code.:

Synonyms:2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

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Chemical Property of 2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

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Technology Process of 2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

There total 7 articles about 2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6684-39-5
2-chloropyridine-5-sulfonyl chloride

: 1450620-71-9
benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1450620-72-0
2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

Guidance literature:: benzyl 4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate; With trifluorormethanesulfonic acid; trifluoroacetic acid; for 1h;

2-chloropyridine-5-sulfonyl chloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 136476-20-5
1-bromo-4-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1450620-72-0
2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / 6 h / 20 °C

2.1: toluene-4-sulfonic acid / 40 h / 20 °C

3.1: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

4.1: trifluorormethanesulfonic acid; trifluoroacetic acid / 1 h

4.2: 1 h / 20 °C

With osmium(VIII) oxide; trifluorormethanesulfonic acid; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; trifluoroacetic acid; sodium t-butanolate; ruphos; In 1,4-dioxane;

Reference yield:

: 1361218-24-7
2-(4-bromophenyl)-3,3,3-trifluoro-1,2-propanediol

: 1450620-72-0
2-(4-(4-((6-chloro-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-3,3,3-trifluoro-1,2-propanediol

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / 40 h / 20 °C

2.1: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

3.1: trifluorormethanesulfonic acid; trifluoroacetic acid / 1 h

3.2: 1 h / 20 °C

With trifluorormethanesulfonic acid; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; toluene-4-sulfonic acid; trifluoroacetic acid; sodium t-butanolate; ruphos; In 1,4-dioxane;