Isopropylhydrazine hydrochloride

Base Information

• Chemical Name: Isopropylhydrazine hydrochloride
• CAS No.: 16726-41-3
• Molecular Formula: C₃H₁₀N₂*2ClH
• Molecular Weight: 147.048
• Hs Code.: 2928000090
• European Community (EC) Number: 240-784-3
• UNII: ME9AXJ875J
• DSSTox Substance ID: DTXSID5066112
• Mol file: 16726-41-3.mol

Synonyms:1-isopropylhydrazine;1-isopropylhydrazine hydrochloride;1-isopropylhydrazine monohydrochloride;1-isopropylhydrazine oxalate;1-isopropylhydrazine sulfate;1-isopropylhydrazine sulfate (2:1);isopropylhydrazine

Chemical Property of Isopropylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: COA
• Vapor Pressure: 15.5mmHg at 25°C
• Melting Point: 115-118 °C
• Refractive Index: 1.42
• Boiling Point: 120.1 °C at 760 mmHg
• Flash Point: 24.8 °C
• PSA: 38.05000
• Density: 0.815g/cm3
• LogP: 1.75130
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 110.0610761
• Heavy Atom Count: 6
• Complexity: 18.9

Purity/Quality:

99% ^*data from raw suppliers

Isopropylhydrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NN.Cl
• Uses: Potent monoamine oxidase inhibitor

Technology Process of Isopropylhydrazine hydrochloride

There total 7 articles about Isopropylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-(isopropyl)hydrazinecarboxylate (16689-35-3) → isopropylhydrazine hydrochloride (70629-60-6,73941-11-4,16726-41-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 100.0%

di-tert-butyl 1-isopropylhydrazine-1,2-dicarboxylate → isopropylhydrazine hydrochloride (70629-60-6,73941-11-4,16726-41-3)

Guidance literature:

di-tert-butyl 1-isopropylhydrazine-1,2-dicarboxylate; With acetyl chloride; In methanol; at 0 ℃; Sealed tube;

With hydrogenchloride; In methanol; at 20 ℃; Sealed tube;

DOI:10.1039/C9CC00492K

Reference yield: 58.6%

tert-butyl isopropylidenecarbazate (16689-34-2) → isopropylhydrazine hydrochloride (70629-60-6,73941-11-4,16726-41-3)

Guidance literature:

tert-butyl isopropylidenecarbazate; With borane-THF; at 20 ℃; for 0.166667h;

With hydrogenchloride; In water; for 1h; Reflux;

upstream raw materials:

1-isopropylhydrazinecarboxylic acid tert-butyl ester

tert-butyl 2-(isopropyl)hydrazinecarboxylate

1-(isopropyl)-2-tert-butoxycarbonylhydrazine acetate

tert-butyl isopropylidenecarbazate

Downstream raw materials:

Z-Ala-HN-NH-CH(CH₃)2

benzyl 2-(4-((1,3-dioxolan-2-yl)methyl)-5-(4-fluorophenyl)-1-isopropyl-1H-pyrazol-3-yl)ethylcarbamate

5-amino-3-(3-ethoxy-4-methoxyphenyl)-1-isopropyl-1H-pyrazole-4-carbonitrile

3-benzyloxy-5-(2,3-dihydrobenzo[1,4]dioxin-6-yl)-1-isopropyl-1H-pyrazole

Refernces

• 1、 -. "Synthesis method for pharmaceutically acceptable salt of alkylhydrazine". Paragraph 0051; 0052. . Retrieved 2017/08/28.
• 2、 -. "PROTEIN KINASE INHIBITORS". Paragraph 0236. . Retrieved 2015/07/15.