2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine

Base Information

Chemical Name:2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine
CAS No.:1360555-10-7
Molecular Formula:C₂₃H₁₄ClF₃N₂
Molecular Weight:410.826
Hs Code.:

Synonyms:2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine

Chemical Property:

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Technology Process of 2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine

There total 5 articles about 2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1360554-90-0
2-(azidobenzylideneamino)-1-(4-chlorophenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1

: 1360555-10-7
2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine

Guidance literature:: With triphenylphosphine; In toluene; at 80 ℃; for 8h; regioselective reaction;
DOI:10.1002/ejoc.201100710

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1360555-10-7
2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine; acetic acid

2: ethanol / 3 h / 20 °C

3: ethanol / 50 °C

4: triphenylphosphine / toluene / 8 h / 80 °C

With piperidine; acetic acid; triphenylphosphine; In ethanol; toluene; 3: Aza-Wittig reaction;
DOI:10.1002/ejoc.201100710

Reference yield:

: 1360555-43-6
C₁₆H₉ClF₃N₃O

: 1360555-10-7
2-(4-chlorophenyl)-3-[4-(trifluoromethyl)benzylidene]-3H-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 3 h / 20 °C

2: ethanol / 50 °C

3: triphenylphosphine / toluene / 8 h / 80 °C

With triphenylphosphine; In ethanol; toluene; 2: Aza-Wittig reaction;
DOI:10.1002/ejoc.201100710