1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol

Base Information

• Chemical Name: 1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol
• CAS No.: 80448-19-7
• Molecular Formula: C₂₀H₂₇NO₃
• Molecular Weight: 329.439
• Mol file: 80448-19-7.mol

Synonyms:1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol

Chemical Property of 1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol

There total 2 articles about 1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzylmethylamino)-2-acetoxy-3-<4-(2-methoxyethyl)phenoxy>propane (80448-16-4) → 1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol (80448-19-7)

Guidance literature:

With potassium hydroxide; In methanol; for 0.5h; Yield given; Heating;

DOI:10.1021/jo00345a046

Reference yield:

3-[4-(2-methoxyethyl)phenoxy]propylene (80448-05-1) → 1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol (80448-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) (C₆H₅CN)2PdCl₂, 2.) CH₃COOAg, (CH₃COO)4Pb / 1.) THF, -50 deg C, 1 h, 2.) THF, -50 deg C to room temperature, 2.5 h

2: KOH / methanol / 0.5 h / Heating

With lead(IV) acetate; potassium hydroxide; bis(benzonitrile)palladium(II) dichloride; silver(I) acetate; In methanol;

DOI:10.1021/jo00345a046

Reference yield: 95.0%

1-(benzylmethylamino)-3-<4-(2-methoxyethyl)phenoxy>propan-2-ol (80448-19-7) → 1-[4-(2-Methoxy-ethyl)-phenoxy]-3-methylamino-propan-2-ol (80448-17-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 15h; under 760 Torr; Ambient temperature;

DOI:10.1021/jo00345a046

upstream raw materials:

1-(benzylmethylamino)-2-acetoxy-3-<4-(2-methoxyethyl)phenoxy>propane

3-[4-(2-methoxyethyl)phenoxy]propylene

Downstream raw materials:

1-[4-(2-Methoxy-ethyl)-phenoxy]-3-methylamino-propan-2-ol