80448-05-1Relevant articles and documents
Asymmetric synthesis of (S)-metoprolol via sharpless asymmetric dihydroxylation induced by a recoverable polymer ligand QN-AQNOPEG-OMe
Cheng, Sikun,Liu, Xueying,Wang, Pingan,Li, Xiaoye,He, Wei,Zhang, Shengyong
, p. 516 - 519 (2012)
The catalytic asymmetric dihydroxylation (AD) discovered by Sharpless, a Nobel Prize winner in 2001, has rapidly become an invaluable synthetic tool in the possibility of converting prochiral olefins to chiral vicinal diols. After our long-running investi
A New Route to (+/-) Metoprolol
Gurjar, M.K.,Joshi, Shreerang V,Sastry, B.S.,Rao, A V Rama
, p. 3489 - 3496 (2007/10/02)
Synthesis of 4-(2-methoxyethyl)phenol (5) from phenol is described.The derived aryloxyallyl ether (6) is converted into (+/-)-metoprolol (10) by involving dihydroxylation reaction with OsO4 and NMO.