7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine

Base Information

Chemical Name:7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine
CAS No.:1027183-54-5
Molecular Formula:C₁₈H₂₃FN₂O₂SSi₂
Molecular Weight:406.628
Hs Code.:

Synonyms:7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine

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Chemical Property of 7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine

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Technology Process of 7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine

There total 7 articles about 7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 1027183-54-5
7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: CH₃ONa / methanol / 5 h / Ambient temperature

2: dimethylformamide / 2 h / Ambient temperature

3: 1.) CH₃ONa / 1.) CH₃OH, 30 min, 10 deg C, 2.) CH₃OH, reflux, 6 h

4: H₂O / 12 h / Ambient temperature

5: 5percent aq. NaOH / 2 h

6: ammonium sulfate / 4 h / Heating

With sodium hydroxide; ammonium sulfate; sodium methylate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570310208

Reference yield:

: 398-42-5
2-formyl-2-(4-fluorophenyl) acetonitrile

: 1027183-54-5
7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / N-methylmorpholine / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) CH₃ONa / 1.) CH₃OH, 30 min, 10 deg C, 2.) CH₃OH, reflux, 6 h

3: H₂O / 12 h / Ambient temperature

4: 5percent aq. NaOH / 2 h

5: ammonium sulfate / 4 h / Heating

With 4-methyl-morpholine; sodium hydroxide; ammonium sulfate; sodium methylate; In dichloromethane; water;
DOI:10.1002/jhet.5570310208

Reference yield:

: 2-(4-fluorophenyl)-3-(p-toluenesulfonato)acrylonitrile

: 1027183-54-5
7-(4-Fluoro-phenyl)-2,4-bis-trimethylsilanyloxy-thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) CH₃ONa / 1.) CH₃OH, 30 min, 10 deg C, 2.) CH₃OH, reflux, 6 h

2: H₂O / 12 h / Ambient temperature

3: 5percent aq. NaOH / 2 h

4: ammonium sulfate / 4 h / Heating

With sodium hydroxide; ammonium sulfate; sodium methylate; In water;
DOI:10.1002/jhet.5570310208