1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione

Base Information

Chemical Name:1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
CAS No.:170855-86-4
Molecular Formula:C₂₈H₂₈N₄O₇S
Molecular Weight:564.619
Hs Code.:

Synonyms:1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione

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Chemical Property of 1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione

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Technology Process of 1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione

There total 9 articles about 1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7379-14-8
2-Chloro-1-cyclopropylethan-1-one

: 170855-86-4
1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 87.1 percent / K₂CO₃, KI / dimethylformamide / 15 h / Ambient temperature

2: 98.5 percent / H₂ / 10percent Pd/C / methanol / 40 h

3: 1.) triethylamine / 1.) THF, 15 min, 2.) THF, 3 h

With hydrogen; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00083-7

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 170855-86-4
1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / sodium methoxide / methanol / 5 h / Heating

2: 87.1 percent / K₂CO₃, KI / dimethylformamide / 15 h / Ambient temperature

3: 98.5 percent / H₂ / 10percent Pd/C / methanol / 40 h

4: 1.) triethylamine / 1.) THF, 15 min, 2.) THF, 3 h

With hydrogen; sodium methylate; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00083-7

Reference yield:

: 28488-91-7
2-cyclopropyl-1-diazo-2-ethanone

: 170855-86-4
1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylthio)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: concd aq. HCl / diethyl ether / 3 h / -20 °C

2: 87.1 percent / K₂CO₃, KI / dimethylformamide / 15 h / Ambient temperature

3: 98.5 percent / H₂ / 10percent Pd/C / methanol / 40 h

4: 1.) triethylamine / 1.) THF, 15 min, 2.) THF, 3 h

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00083-7