2-Chloro-1-cyclopropylethan-1-one

Base Information

• Chemical Name: 2-Chloro-1-cyclopropylethan-1-one
• CAS No.: 7379-14-8
• Molecular Formula: C5H7ClO
• Molecular Weight: 118.56
• European Community (EC) Number: 810-167-9
• DSSTox Substance ID: DTXSID70499386
• Wikidata: Q82350120
• Mol file: 7379-14-8.mol

Synonyms:2-Chloro-1-cyclopropylethan-1-one;7379-14-8;2-chloro-1-cyclopropylethanone;2-CHLORO-1-CYCLOPROPYL-ETHANONE;chloroacetyl-cyclopropane;SCHEMBL1132078;DTXSID70499386;ZXWAHROJUXWVCU-UHFFFAOYSA-N;AKOS006384446;EN300-142197;Z1205657701

Chemical Property of 2-Chloro-1-cyclopropylethan-1-one

Chemical Property:

• Melting Point: 128-131 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• Boiling Point: 158.941 °C at 760 mmHg
• Flash Point: 53.655 °C
• PSA: 17.07000
• Density: 1.237 g/cm³
• LogP: 1.20430
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 118.0185425
• Heavy Atom Count: 7
• Complexity: 86.1

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-1-cyclopropylethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1C(=O)CCl

Technology Process of 2-Chloro-1-cyclopropylethan-1-one

There total 6 articles about 2-Chloro-1-cyclopropylethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + cyclopropanecarboxylic acid chloride (4023-34-1) → Fluormethyl-cyclopropyl-keton (3794-04-5) + 2-Chloro-1-cyclopropylethan-1-one (7379-14-8)

Guidance literature:

Multistep reaction; (i) ether, (ii) HF, KF;

Reference yield:

2-cyclopropyl-1-diazo-2-ethanone (28488-91-7) → 2-Chloro-1-cyclopropylethan-1-one (7379-14-8)

Guidance literature:

With hydrogenchloride; In diethyl ether; at -20 ℃; for 3h;

DOI:10.1016/S0968-0896(97)00083-7

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + cyclopropanecarboxylic acid chloride (4023-34-1) → 2-Chloro-1-cyclopropylethan-1-one (7379-14-8)

Guidance literature:

Multistep reaction; (i) ether, (ii) aq. HCl;

upstream raw materials:

Cyclopropyl methyl ketone

diazomethane

cyclopropanecarboxylic acid chloride

2-cyclopropyl-1-diazo-2-ethanone

Downstream raw materials:

Fluormethyl-cyclopropyl-keton

2-(8-Benzyloxy-2-cyclopropylindolizin-1-yl)acetamide

1,5-bis-(cyclopropylcarbonylmethyl)-3-{N'-[m-(carboxymethylsulfoxy)phenyl]ureido}-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione

1,5-Bis-(cyclopropylcarbonylmethyl)-3-(N'-(m-(carboethoxymethoxy)phenyl)ureido)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione