di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate

Base Information

• Chemical Name: di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate
• CAS No.: 1330063-61-0
• Molecular Formula: C₂₇H₄₅N₅O₇
• Molecular Weight: 551.684
• Mol file: 1330063-61-0.mol

Synonyms:di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate

Chemical Property of di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate

There total 3 articles about di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) + {2-[(2-amino-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester (161038-11-5) → di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate (1330063-61-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 4h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate (1330063-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 20 °C

1.2: 2 h / 60 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 4 h

With 1H-imidazole; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

Reference yield:

2,2',2''-triaminotriethylamine (4097-89-6) → di-tert-butyl ((2-(3-(Cbz-amino)propanamido)ethyl)azanediyl)bis(ethane-2,1-diyl)dicarbamate (1330063-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 20 °C

1.2: 2 h / 60 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 4 h

With 1H-imidazole; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

2,2',2''-triaminotriethylamine

3-(benzyloxycarbonylamino)propanoic acid

{2-[(2-amino-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester

Downstream raw materials:

tetra-tert-butyl ((((2-3-Cbz-aminopropanamido)ethyl)azanediyl)bis(ethane-2,1-diyl))bis(azanetriyl)tetrakis(ethane-2,1-diyl)tetracarbamate