4097-89-6

Usage

Uses

Used in Coordination Chemistry:
Tris(2-aminoethyl)amine is used as a tetradentate chelating ligand for forming stable complexes with transition metals. This application is crucial in various chemical reactions and processes that involve metal coordination.
Used as a Carbon Dioxide Absorbent:
Tris(2-aminoethyl)amine serves as a carbon dioxide absorbent, making it a valuable component in industries where CO2 removal is essential, such as in the medical field for respirator applications or in industrial processes to control greenhouse gas emissions.
Used in Peptide Synthesis:
In the field of peptide synthesis, Tris(2-aminoethyl)amine acts as a reagent for the cleavage of the fluorenylmethyloxycarbonyl (Fmoc) group. This function is vital for the synthesis of peptides and proteins, as it allows for the selective removal of protecting groups during the assembly process.
Used in the Synthesis of Tris-urea and -thiourea Derivatives:
Tris(2-aminoethyl)amine is also utilized in the reaction with aryl isocyanates and isothiocyanates to produce tris-urea and -thiourea derivatives. These derivatives have potential applications in various fields, including pharmaceuticals and materials science.

Hazard

A poison by ingestion and skin contact.

Safety Profile

A poison by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx.

Purification Methods

For a separation from a mixture containing 62% TRIEN, see entry under triethylenetetramine. Also purify it by conversion to the hydrochloride (see below), recrystallise it and regenerate the free base [Xie & Hendrickson J Am Chem Soc 109 6981 1987]. [Beilstein 4 H 256, 4 II 695, 4 III 545, 4 IV 1250.]

InChI:InChI=1/C6H18N4/c7-1-4-10(5-2-8)6-3-9/h1-9H2/p+4

Upstream product

• 151-56-4 ethyleneimine 
• 111-40-0 3-azapentane-1,5-diamine 
• 102-71-6 triethanolamine 
• 147631-17-2 CH₃Ge(NHCH₂CH₂)3N 
• 147631-19-4 (CH₃)3CGe(NHCH₂CH₂)3N 
• 44905-58-0 triaminotriethylamine hydrogen chloride 
• 817-09-4 tris-(2-chloroethyl)amine hydrochloride 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 98846-92-5 tris[2-(N-tosylaminoethyl)]amine 
• 31701-37-8 1-phenylazasilantrane 
• 129323-84-8 N-{2-[Bis-(2-amino-ethyl)-amino]-ethyl}-benzamide 
• 121458-97-7 tris-<2-(2'-hydroxy-4'-methoxybenzylideneethyl)>amine 
• 141621-34-3 C₃₀H₃₀N₄O₉ 
• 139112-38-2 1,1',1''-(nitrilotris(ethane-2,1-diyl))tris(1H-pyrrole-2,5-dione) 
• 155019-77-5 2,2',2''-tris<(pentafluorophenyl)amino>triethylamine 
• 138805-06-8 tris-(2-(2-hydroxy-4-methylbenzylideneamino)ethyl)amine 
• 146559-08-2 N,N',N''-tri(2,3-dihydroxybenzylidene)-2,2',2''-triaminotriethylamine 
• 155019-79-7 2,2',2''-tris<(3,5-bis(trifluoromethyl)phenyl)amino>triethylamine 
• 131933-29-4 C₃₉H₄₈N₄O₁₅ 
• 125928-16-7 C₃₆H₄₈N₄O₁₂ 
• 125928-19-0 C₃₆H₄₈N₄O₁₂ 
• 4425-82-5 9-methylene-fluorene 

Relevant academic research and scientific papers

Tris(2-aminoethyl)amine synthesis process

The invention discloses a tris(2-aminoethyl)amine synthesis process, and belongs to the technical field of compound preparation. The tris(2-aminoethyl)amine synthesis process includes the steps of taking triethanolamine as a starting material, putting the triethanolamine, thionyl chloride and a catalyst DMF in a reactor, heating the three to generate tris(2-chloroethyl)amine hydrochloride, dissolving separated tris(2-chloroethyl)amine hydrochloride concentrate and ammonia water in an organic solvent in a reactor, putting the solution in the reactor, carrying out a reaction while heating to obtain tris(2-aminoethyl)amine hydrochloride, and reacting the tris(2-aminoethyl)amine hydrochloride with sodium hydroxide to obtain the tris(2-aminoethyl)amine. The tris(2-aminoethyl)amine synthesis process has the advantages of short reaction route and high controllability.

N - alkylated three amidogen star-shaped ultra-low molecular inhibitors of preparation method

The invention discloses a N - alkylated three amidogen star-shaped ultra-low molecular inhibitors of the preparation method, the method using triethanolamine as raw materials, in solution to the triethanolamine sequentially carry out the oxidation reaction, amination reaction, so as to obtain the final product The process of the invention is simple, low cost, mild condition, the safety is good, high yield, is suitable for industrial production. The invention prepared three amidogen N - alkylation of star-shaped ultra-low molecular inhibitor molecule with the size of the structure can be accurately controlled, the terminal group to a primary amine group and group large characteristic of the density, the bentonite and be better hydration of the stolen are there is a strong function of inhibiting, at a relatively low quantity that can effectively inhibit hydration under expansion, has strong of temperature performance, which is capable of reach 220 °C.

Preparation method of tris(2-aminoethyl)amine

The invention discloses a preparation method of tris(2-aminoethyl)amine, and belongs to the technical field of compound preparation. According to the method, trolamine is used as starting materials; firstly, the trolamine, thionyl chloride and catalysts DMF are put into a reactor; under the heating conditions, tris(2-chloroethyl)amine hydrochloride is generated; then, the purified tris(2-chloroethyl)amine hydrochloride and ammonium hydroxide are dissolved into an organic solvent and put into the reactor; reaction is performed under the heating condition to obtain the tris(2-aminoethyl)amine hydrochloride; finally, the tris(2-aminoethyl)amine hydrochloride reacts with sodium hydroxide to obtain tris(2-aminoethyl)amine. The reaction route is short; the controllability is high.

HYDRAZIDE CONJUGATES AS IMAGING AGENTS

The present disclosure is directed to diagnostic agents. More specifically, the disclosure is directed to compounds, diagnostic agents, compositions, and kits for detecting and/or imaging and/or monitoring a pathological disorder associated with coronary plaque, carotid plaque, aortic plaque, plaque of the arterial vessel, aneurism, vasculitis, and other diseases of the arterial wall. In addition, the disclosure is directed to methods of detecting and/or imaging and/or monitoring changes in the arterial wall, including expansive and constrictive remodeling, total vessel wall area, internal lumen size, and exterior artery perimeter.

Synthesis and interconversions of azagermatranes

The syntheses of the first examples of the title compounds, namely, ZGe(NRCH2CH2)3N (4, R = H, Z = Me; 5, R = Me, Z = Me; 6, R = H, Z = t-Bu; 7, R = Me, Z = t-Bu; 8, R = Me, Z = NMe2) are reported. Syntheses of the new compounds MeGe(NMe2)3 and t-BuGe(NMe2)3 and an improved synthesis of Ge(NMe2)4 are also recorded. The azagermatranes 5 and 7 are transformed to 4 and 6, respectively, in the presence of (H2NCH2CH2)3N. This reaction was not found to be reversible, however. Azagermatranes 4 or 5 and 6 or 7 in the presence of (HOCH2CH2)3N easily react to give MeGe(OCH2CH2)3N and t-BuGe(OCH2CH2)3N, respectively. Because of steric factors, one or more of compounds 6-8 may display weakened transannular Ge←N bonding or even an absence of this bonding.