methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate

Base Information

Chemical Name:methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate
CAS No.:1401031-19-3
Molecular Formula:C₂₀H₂₄FNO₃
Molecular Weight:345.414
Hs Code.:

Synonyms:methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate

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Chemical Property of methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate

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Technology Process of methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate

There total 3 articles about methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1401031-16-0
methyl 2-cyano-2-[(4Z)-1-oxaspiro[5.5]undecan-4-ylidene]acetate

: 352-13-6
4-flourophenylmagnesium bromide

: 1401031-19-3
methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h; Cooling with ice;
DOI:10.1021/jm4010829

Reference yield:

: spirotetrahydropyran-4-one

: 1401031-19-3
methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate; acetic acid / benzene / Reflux; Dean-Stark

2: copper(l) iodide / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C / Cooling with ice

With copper(l) iodide; ammonium acetate; acetic acid; In tetrahydrofuran; diethyl ether; benzene; 1: |Knoevenagel Condensation / 2: |Michael Addition;
DOI:10.1021/jm4010829