1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine

Base Information

• Chemical Name: 1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine
• CAS No.: 176910-91-1
• Molecular Formula: C₂₁H₃₀N₂O₃S₂
• Molecular Weight: 422.613
• Mol file: 176910-91-1.mol

Synonyms:1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine

Chemical Property of 1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine

There total 1 articles about 1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanesulfonyl chloride (124-63-0) + 1-<1-(2-benzothiophenyl)cyclohextl>-4-(2-hydroxy-ethyl)-piperazine (153947-30-9) → 1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine (176910-91-1)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 2.5h;

DOI:10.1002/(SICI)1099-1344(199603)38:3<299::AID-JLCR847>3.0.CO;2-E

Reference yield:

1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine (176910-91-1) → 1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-(2-bromoethyl)piperazine + 1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-(2-chloroethyl)piperazine

Guidance literature:

With lithium bromide; In dichloromethane; for 20h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1002/(SICI)1099-1344(199603)38:3<299::AID-JLCR847>3.0.CO;2-E

Reference yield:

1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-<2-(methylsulfonyloxy)ethyl>piperazine (176910-91-1) → 1-<1-(2-benzo(b)thiophenyl)cyclohexyl>-4-(2-fluoroethyl)piperazine

Guidance literature:

With potassium fluoride; [2.2.2]cryptande; lithium bromide; Yield given. Multistep reaction; 1.) CH₂Cl₂, reflux, 20 h, 2.) acetonitrile, reflux, 20 h;

DOI:10.1002/(SICI)1099-1344(199603)38:3<299::AID-JLCR847>3.0.CO;2-E

upstream raw materials:

methanesulfonyl chloride

1-<1-(2-benzothiophenyl)cyclohextl>-4-(2-hydroxy-ethyl)-piperazine