1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:182126-65-4
Molecular Formula:C₁₈H₁₉N₃O₅
Molecular Weight:357.366
Hs Code.:

Synonyms:1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione

There total 5 articles about 1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 182126-82-5
Toluene-4-sulfonic acid (2R,3S,5R)-2-benzylcarbamoyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 182126-65-4
1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1.) 0 deg C, 2 h, 2.) room temperature, 5 h;
DOI:10.1021/jo9606259

Reference yield: 70.0%

: 182126-81-4
Methanesulfonic acid (2R,3S,5R)-2-benzylcarbamoyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 182126-65-4
1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione

: Benzyl-carbamic acid (9R,10R)-4-methyl-5-oxo-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.0^2,7]dodeca-3,6-dien-10-ylmethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; Yields of byproduct given; 1.) 0 deg C, 2 h, 2.) room temperature, 20 h;
DOI:10.1021/jo9606259

Reference yield:

: 100-46-9
benzylamine

: 182126-65-4
1-((4aS,6R,7aR)-1-Benzyl-2-oxo-hexahydro-furo[3,2-d][1,3]oxazin-6-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) pyridine / 1.) THF, reflux, 2.) overnight

2: 70 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) room temperature, 20 h

With pyridine; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo9606259