(2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde

Base Information

• Chemical Name: (2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde
• CAS No.: 1228772-75-5
• Molecular Formula: C₁₉H₁₈N₄O₄
• Molecular Weight: 366.376

Synonyms:(2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde

Chemical Property of (2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde

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Technology Process of (2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde

There total 1 articles about (2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-[4-[(2R)-2-[(1R)-2-(4-cyanoanilino)-1-hydroxy-2-oxoethyl]-3-oxomorpholin-4-yl]phenyl]carbamate (1228772-74-4) → (2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde (1228772-75-5)

Guidance literature:

With trifluoroacetic acid; methoxybenzene; at 0 ℃; for 1h;

Reference yield:

(2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde (1228772-75-5) + methanesulfonyl chloride (124-63-0) → (2R)-N-(4-cyanophenyl)-2-hydroxy-2-[(2R)-4-[4-(methanesulfonamido)phenyl]-3-oxomorpholin-2-yl]acetamide (1228772-84-6)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

potassium cyanate (590-28-3) + (2R)-2-[(2R)-4-(4-aminophenyl)-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxyacetamde (1228772-75-5) → (2R)-2-[(2R)-4-[4-(carbamoylamino)phenyl]-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxy acetamide (1228772-83-5)

Guidance literature:

With acetic acid; In water; at 40 - 50 ℃; for 3h;

upstream raw materials:

tert-butyl N-[4-[(2R)-2-[(1R)-2-(4-cyanoanilino)-1-hydroxy-2-oxoethyl]-3-oxomorpholin-4-yl]phenyl]carbamate

Downstream raw materials:

(2R)-N-(4-cyanophenyl)-2-hydroxy-2-[(2R)-4-[4-(methanesulfonamido)phenyl]-3-oxomorpholin-2-yl]acetamide

(2R)-2-[(2R)-4-[4-(carbamoylamino)phenyl]-3-oxomorpholin-2-yl]-N-(4-cyanophenyl)-2-hydroxy acetamide

[(lR)-1-[(2R)-4-(4-acetamidophenyl)-3-oxomorpholin-2-yl]-2-(4-cyanoanilino)-2-oxoethyl]acetate

(2R)-N-(4-cyanophenyl)-2-hydroxy-2-[(2R)-3-oxo-4-[4-(3-oxomorpholin-4-yl)phenyl]morpholin-2-yl]acetamide

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