6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid

Base Information

• Chemical Name: 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid
• CAS No.: 109786-94-9
• Molecular Formula: C₂₀H₂₆N₂O₅
• Molecular Weight: 374.437
• Mol file: 109786-94-9.mol

Synonyms:6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid

Chemical Property of 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid

There total 4 articles about 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

ethyl 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoate (109786-93-8) → 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid (109786-94-9)

Guidance literature:

With potassium hydroxide; at 40 ℃; for 1h;

DOI:10.1021/jm00393a022

Reference yield:

1-[2-hydroxy-3-[(4-methoxyphenyl)methoxy]propyl]-1H-imidazole (84727-35-5) → 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid (109786-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMSO, 18 deg C, 5 min, 2.) DMSO, 16 h

2: 0.5 M H₂SO₄ / 0.42 h

3: 39 percent / benzene / 1 h

4: 57 percent / ethanolic KOH / 1 h / 40 °C

With potassium hydroxide; sulfuric acid; sodium hydride; In benzene;

DOI:10.1021/jm00393a022

Reference yield:

4-<2-(1H-imidazol-1-yl)-1-<<(4-methoxyphenyl)methoxy>methyl>ethoxy>butanal (109786-92-7) → 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoic acid (109786-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / benzene / 1 h

2: 57 percent / ethanolic KOH / 1 h / 40 °C

With potassium hydroxide; In benzene;

DOI:10.1021/jm00393a022

upstream raw materials:

ethyl 6-(2-(1H-imidazol-1-yl)-1-{[(4-methoxyphenyl)methoxy]methyl}ethoxy)-2(E)-hexenoate

1-[2-hydroxy-3-[(4-methoxyphenyl)methoxy]propyl]-1H-imidazole

4-<2-(1H-imidazol-1-yl)-1-<<(4-methoxyphenyl)methoxy>methyl>ethoxy>butanal

4-<2-(1H-imidazol-1-yl)-1-<<(4-methoxyphenyl)methoxy>methyl>ethoxy>butanal ethylene acetal