(E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid

Base Information

Chemical Name:(E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid
CAS No.:1370333-02-0
Molecular Formula:C₃₃H₃₀N₂O₂S
Molecular Weight:518.679
Hs Code.:

Synonyms:(E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid

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Chemical Property of (E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid

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Technology Process of (E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid

There total 6 articles about (E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1370333-10-0
4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)benzaldehyde

: 372-09-8
cyanoacetic acid

: 1370333-02-0
(E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid

Guidance literature:: With ammonium acetate; In acetic acid; at 90 - 100 ℃; for 12h; Inert atmosphere;
DOI:10.1002/asia.201100777

Reference yield:

: 1384096-13-2
1-(4-tert-butylphenyl)-5-bromo-2-methylindoline

: 1370333-02-0
(E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 24 h / 90 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -40 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

2.3: 24 h / 90 °C / Inert atmosphere

3.1: ammonium acetate / acetic acid / 12 h / 90 - 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; ammonium acetate; In tetrahydrofuran; hexane; acetic acid; N,N-dimethyl-formamide; 1.1: Stille coupling / 2.3: Stille coupling / 3.1: Knoevenagel condensation;
DOI:10.1002/asia.201100777

Reference yield:

: 1283610-08-1
1-(4-tert-butylphenyl)-2-methylindoline

: 1370333-02-0
(E)-3-(4-(5-(1-(4-tert-butylphenyl)-2-methylindolin-5-yl)thiophen-2-yl)phenyl)-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dichloromethane / 6 h / 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 24 h / 90 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -40 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

3.3: 24 h / 90 °C / Inert atmosphere

4.1: ammonium acetate / acetic acid / 12 h / 90 - 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; n-butyllithium; ammonium acetate; In tetrahydrofuran; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; 2.1: Stille coupling / 3.3: Stille coupling / 4.1: Knoevenagel condensation;
DOI:10.1002/asia.201100777