tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate

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Chemical Name:tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate
CAS No.:1146167-92-1
Molecular Formula:C₂₁H₂₉BrN₂O₃S
Molecular Weight:469.443
Hs Code.:

Synonyms:tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate

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Chemical Property of tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate

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Technology Process of tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate

There total 1 articles about tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 848244-00-8
tert-butyl 5-bromo-6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylate

: 2675-89-0
2-chloro-N,N-dimethylacetamide

: 1146167-92-1
tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate

Guidance literature:: tert-butyl 5-bromo-6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

2-chloro-N,N-dimethylacetamide; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 1h;
DOI:10.1016/j.tetlet.2009.01.109

Reference yield: 66.0%

: 1146167-92-1
tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate

: 163105-89-3,600726-67-8
2-methoxy-pyridine-5-boronic acid

: 6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-5-(6-methoxypyridin-3-yl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid

Guidance literature:: tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate; 2-methoxy-pyridine-5-boronic acid; With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 5h; Inert atmosphere;

Acidic conditions;
DOI:10.1016/j.tetlet.2009.01.109

Reference yield: 40.0%

: 1146167-92-1
tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-5-(3-methoxyphenyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid

Guidance literature:: tert-butyl 5-bromo-6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-4H-thieno[3,2-b]pyrrole-2-carboxylate; 3-methoxyphenylboronic acid; With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 5h; Inert atmosphere;

Acidic conditions;
DOI:10.1016/j.tetlet.2009.01.109