Technology Process of (S)-1-(2-methoxyphenoxy)-3-nitropropan-2-ol
There total 6 articles about (S)-1-(2-methoxyphenoxy)-3-nitropropan-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(I) trifluoromethanesolfonate toluene complex; (+)-6,6'-(((1R,2R,4R,5R)-bicyclo[2.2.2]octane-2,5-diylbis(azanediyl))bis(methylene))bis(2,4-di-tert-butylphenol);
In
methanol;
at 40 ℃;
enantioselective reaction;
Molecular sieve;
DOI:10.1021/ol3030023
- Guidance literature:
-
With
glucose dehydrogenase; D-glucose; SyADH from sphingobium yanoikuyae; nicotinamide adenine dinucleotide phosphate;
In
aq. acetate buffer;
at 30 ℃;
for 1h;
pH=5;
Solvent;
stereoselective reaction;
Enzymatic reaction;
DOI:10.1039/c9ob00051h
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / acetone / 20 °C
2: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / 1,4-dioxane; water / 3 h / 20 °C
3: (+)-6,6'-(((1R,2R,4R,5R)-bicyclo[2.2.2]octane-2,5-diylbis(azanediyl))bis(methylene))bis(2,4-di-tert-butylphenol); copper(I) trifluoromethanesolfonate toluene complex / methanol / 40 °C / Molecular sieve
With
2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; copper(I) trifluoromethanesolfonate toluene complex; (+)-6,6'-(((1R,2R,4R,5R)-bicyclo[2.2.2]octane-2,5-diylbis(azanediyl))bis(methylene))bis(2,4-di-tert-butylphenol); potassium carbonate;
In
1,4-dioxane; methanol; water; acetone;
3: |Henry Nitro Aldol Condensation;
DOI:10.1021/ol3030023
