N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

Base Information

Chemical Name:N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide
CAS No.:1610706-30-3
Molecular Formula:C₂₂H₂₅N₉O₂
Molecular Weight:447.5
Hs Code.:

Synonyms:N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

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Chemical Property of N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

Chemical Property:

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Technology Process of N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

There total 6 articles about N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610711-25-5
N-(3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

: 1610706-31-4
N-((1S,3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

: 1610706-30-3
N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

Guidance literature:: With N,N-dimethyl-ethanamine; carbon dioxide; In ethanol; Resolution of racemate;

Reference yield:

: 98140-03-5
6-chloro-N⁴-ethylpyrimidine-4,5-diamine

: 1610706-31-4
N-((1S,3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

: 1610706-30-3
N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium t-butanolate / Dimethyl ether / 2 h / 20 - 43 °C

2: N,O-bis-(trimethylsilyl)-acetamide / 1 h / 55 °C

3: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 15 h / 85 °C

4: triethylamine; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxid hexafluorophosphate / dichloromethane / 16 h / 20 °C

5: N,N-dimethyl-ethanamine; carbon dioxide / ethanol / Resolution of racemate

With N,O-bis-(trimethylsilyl)-acetamide; N,N-dimethyl-ethanamine; carbon dioxide; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxid hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In ethanol; Dimethyl ether; dichloromethane; tert-butyl alcohol;

Reference yield:

: 2134-38-5
ethyl 2-methylpyrimidine-5-carboxylate

: 1610706-31-4
N-((1S,3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

: 1610706-30-3
N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium t-butanolate / Dimethyl ether / 2 h / 20 - 43 °C

2: N,O-bis-(trimethylsilyl)-acetamide / 1 h / 55 °C

3: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 15 h / 85 °C

4: triethylamine; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxid hexafluorophosphate / dichloromethane / 16 h / 20 °C

5: N,N-dimethyl-ethanamine; carbon dioxide / ethanol / Resolution of racemate

With N,O-bis-(trimethylsilyl)-acetamide; N,N-dimethyl-ethanamine; carbon dioxide; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium-3-oxid hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In ethanol; Dimethyl ether; dichloromethane; tert-butyl alcohol;