2134-38-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Ethyl2-methylpyrimidine-5-carboxylate serves as an essential intermediate in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a valuable building block for the development of new drugs and pesticides, contributing to advancements in healthcare and agriculture.
Used in Antimicrobial and Antifungal Applications:
Due to its reported biological activities, ethyl2-methylpyrimidine-5-carboxylate is used as an antimicrobial and antifungal agent. It can be incorporated into various formulations to combat microbial infections and fungal growth, offering potential solutions for treating infections and preserving materials.
Used in Dye and Pigment Production:
Ethyl2-methylpyrimidine-5-carboxylate is also utilized in the production of dyes and pigments. Its chemical properties allow it to contribute to the color and stability of these products, making it a valuable component in the manufacturing process of various dyes and pigments used in different industries, such as textiles, plastics, and printing inks.

InChI:InChI=1/C8H10N2O2/c1-3-12-8(11)7-4-9-6(2)10-5-7/h4-5H,3H2,1-2H3

Upstream product

• 10601-80-6 ethyl 3,3-diethoxypropanoate 
• 124-42-5 acetamidine hydrochloride 
• 109-94-4 formic acid ethyl ester 
• 80370-42-9 ethyl 2-formyl-3-oxopropanoate 
• 97430-37-0 2-(ethoxycarbonyl)-3-hydroxyacrolein 
• 143-37-3 acetamidine 

Downstream Products

• 1610703-98-4 9-ethyl-8-(2-methylpyrimidin-5-yl)-N-[(3S)-1-(phenylacetyl)pyrrolidin-3-yl]-9H-purin-6-amine 
• 1610706-31-4 N-((1S,3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide 
• 1610706-30-3 N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide 
• 1610711-25-5 N-(3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide 
• 5194-32-1 2-methylpyrimidine-5-carboxylic acid 

Relevant academic research and scientific papers

FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR

The present invention relates to novel fused thiazole derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

N-PHENYL-(2R,5S)DIMETHYLPIPERADINE DERIVATIVE

The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. VIII. Synthesis of Ethyl and Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with N-C-N dinucleophiles such as guanidine, acetamidine or benzamidine afforded in high yields the relative esters of 4-substituted 2-amino-, 2-methyl- or 2-phenyl-5-pyrimidinecarboxylic acids, respectively.These esters were hydrolyzed to the corresponding carboxylic acids, which were converted by heating to 4-substituted 2-pyrimidinamines, 2-methyl or 2-phenylpyrimidines, respectively, generally in excellent yields.The 4-unsubstituted ethyl 2-amino-, 2-methyl- and 2-phenyl-5-pyrimidinecarboxylateswere obtained in moderate yields by reaction of the above dinucleophiles with ethyl 2,2-diformylacetate.These esters were hydrolyzed and the corresponding acids (with the exception of the 2-methyl derivative) were decarboxylated to give 2-pyrimidinamine and 2-phenylpyrimidine in satisfactory yields.