2134-38-5

Basic information

• Product Name: ethyl2-methylpyrimidine-5-carboxylate
• Synonyms: 2-Methyl-5-pyrimidinecarboxylic acid ethyl ester;Ethyl 2-methyl-5-pyrimidinecarboxylate;5-PyriMidinecarboxylic acid, 2-Methyl-, ethyl ester;Ethyl 2-MethylpyriMidine-...
• CAS NO: 2134-38-5
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Product Categories: pyrimidine
• Mol File: 2134-38-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 240℃
• Flash Point: 99℃
• Appearance: /
• Density: 1.13
• Vapor Pressure: 0.039mmHg at 25°C
• Refractive Index: 1.508
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.25±0.22(Predicted)
• CAS DataBase Reference: ethyl2-methylpyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl2-methylpyrimidine-5-carboxylate(2134-38-5)
• EPA Substance Registry System: ethyl2-methylpyrimidine-5-carboxylate(2134-38-5)

Safety Data

• Hazardous Substances Data: 2134-38-5(Hazardous Substances Data)

Usage

General Description

Ethyl2-methylpyrimidine-5-carboxylate is a chemical compound with the molecular formula C9H10N2O2. It is a pyrimidine derivative with a methyl and an ethyl group attached to the pyrimidine ring at the 2 and 5 positions, respectively. ethyl2-methylpyrimidine-5-carboxylate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also reported to have potential biological activities, such as antimicrobial and antifungal properties. Additionally, it is used in the production of dyes and pigments. Overall, ethyl2-methylpyrimidine-5-carboxylate is a versatile chemical with various industrial and biological applications.

InChI:InChI=1/C8H10N2O2/c1-3-12-8(11)7-4-9-6(2)10-5-7/h4-5H,3H2,1-2H3

Upstream product

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• 124-42-5 acetamidine hydrochloride 
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Downstream Products

• 5194-32-1 2-methylpyrimidine-5-carboxylic acid 
• 1610703-98-4 9-ethyl-8-(2-methylpyrimidin-5-yl)-N-[(3S)-1-(phenylacetyl)pyrrolidin-3-yl]-9H-purin-6-amine 
• 1610706-31-4 N-((1S,3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide 
• 1610706-30-3 N-((1R,3R)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide 
• 1610711-25-5 N-(3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}cyclohexyl)-1,3-oxazole-4-carboxamide 

Relevant articles and documents

FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR

The present invention relates to novel fused thiazole derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. VIII. Synthesis of Ethyl and Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with N-C-N dinucleophiles such as guanidine, acetamidine or benzamidine afforded in high yields the relative esters of 4-substituted 2-amino-, 2-methyl- or 2-phenyl-5-pyrimidinecarboxylic acids, respectively.These esters were hydrolyzed to the corresponding carboxylic acids, which were converted by heating to 4-substituted 2-pyrimidinamines, 2-methyl or 2-phenylpyrimidines, respectively, generally in excellent yields.The 4-unsubstituted ethyl 2-amino-, 2-methyl- and 2-phenyl-5-pyrimidinecarboxylateswere obtained in moderate yields by reaction of the above dinucleophiles with ethyl 2,2-diformylacetate.These esters were hydrolyzed and the corresponding acids (with the exception of the 2-methyl derivative) were decarboxylated to give 2-pyrimidinamine and 2-phenylpyrimidine in satisfactory yields.