ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate

Base Information

Chemical Name:ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate
CAS No.:540779-40-6
Molecular Formula:C₄₂H₅₁NO₆
Molecular Weight:665.87
Hs Code.:

Synonyms:ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate

Suppliers and Price of ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate

There total 11 articles about ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 221137-01-5
3-(1-adamantyl)-4-benzyloxyphenylboronic acid

: 540779-39-3
ethyl (E)-4-bromo-3-(3'-tert-butoxycarboxamidopropoxy)cinnamate

: 540779-40-6
ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; for 20h; Heating;
DOI:10.1021/jm030524k

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 540779-40-6
ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 81 percent / K₂CO₃ / acetone / 20 h / Heating

3: 83 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 20 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; acetone;
DOI:10.1021/jm030524k

Reference yield:

: 7781-98-8
ethyl-3-hydroxybenzoate

: 540779-40-6
ethyl (E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-[(3'-tert-butoxycarboxamido)propoxy]cinnamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 53 percent / Br₂; AcOH / 20 h / 20 °C

2.1: 84 percent / K₂CO₃ / acetone / 15 h / Heating

3.1: 91 percent / DIBAL / CH₂Cl₂; hexane / 2 h / -78 °C

4.1: PCC / CH₂Cl₂ / 5 h / 20 °C

5.1: KN(SiMe₃)2 / diethyl ether; tetrahydrofuran / 0.5 h / -78 °C

5.2: 0.28 g / diethyl ether; tetrahydrofuran / -78 - 20 °C

6.1: 92 percent / BBr₃ / CH₂Cl₂ / 2 h / -78 °C

7.1: 81 percent / K₂CO₃ / acetone / 20 h / Heating

8.1: 83 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 20 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; boron tribromide; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium carbonate; potassium carbonate; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; hexane; dichloromethane; acetone;
DOI:10.1021/jm030524k