(4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine

Base Information

Chemical Name:(4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine
CAS No.:1029047-31-1
Molecular Formula:C₁₉H₁₅Cl₂N₅
Molecular Weight:384.268
Hs Code.:

Synonyms:(4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine

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Chemical Property of (4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine

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Technology Process of (4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine

There total 6 articles about (4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1029052-84-3
[5-((1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-pyrimidin-2-yl]-(4-chloro-benzyl)-amine

: 1029047-31-1
(4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine

Guidance literature:: With tetrabutyl ammonium fluoride; water; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1001414-09-0
1-benzenesulfonyl-5-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine

: 1029047-31-1
(4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -40 - 5 °C

1.2: 2 h / -40 - 10 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 35 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.17 h / 0 °C

4.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 150 °C / Microwave irradiation

5.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 20 °C

With triethylsilane; tetrabutyl ammonium fluoride; water; isopropylmagnesium chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 1029052-80-9
(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol

: 1029047-31-1
(4-chlorobenzyl)-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)pyrimidin-2-yl]amine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane / 35 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.17 h / 0 °C

3: 1-methyl-pyrrolidin-2-one / 0.25 h / 150 °C / Microwave irradiation

4: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 20 °C

With triethylsilane; tetrabutyl ammonium fluoride; water; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;