(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol

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Chemical Name:(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol
CAS No.:1029052-80-9
Molecular Formula:C₁₉H₁₅ClN₄O₃S₂
Molecular Weight:446.938
Hs Code.:

Synonyms:(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol

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Chemical Property of (1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol

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Technology Process of (1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol

There total 3 articles about (1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

: 1001414-09-0
1-benzenesulfonyl-5-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine

: 90905-31-0
2-(methylsulfanyl)pyrimidine-5-carbaldehyde

: 1029052-80-9
(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol

Guidance literature:: 1-benzenesulfonyl-5-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at -40 - 5 ℃; for 1h;

2-(methylsulfanyl)pyrimidine-5-carbaldehyde; In tetrahydrofuran; at -40 - 10 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 900514-08-1
5-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine

: 1029052-80-9
(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 15 h / 0 - 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -40 - 5 °C / Inert atmosphere

2.2: 2 h / -40 - 10 °C / Inert atmosphere

With isopropylmagnesium chloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 866546-07-8
5-chloro-1H-pyrrolo[2,3-b]pyridine

: 1029052-80-9
(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-methylsulfanylpyrimidin-5-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Iodine monochloride; pyridine / dichloromethane / 2.33 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 15 h / 0 - 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -40 - 5 °C / Inert atmosphere

3.2: 2 h / -40 - 10 °C / Inert atmosphere

With pyridine; isopropylmagnesium chloride; Iodine monochloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;