1-BOC-4-AMINOINDOLE

Base Information

• Chemical Name: 1-BOC-4-AMINOINDOLE
• CAS No.: 885270-30-4
• Molecular Formula: C₁₃H₁₆N₂O₂
• Molecular Weight: 232.282
• Hs Code.: 2933990090
• Mol file: 885270-30-4.mol

Synonyms:1-Boc-4-aminoindole;tert-Butyl 4-aminoindole-1-carboxylate;

Chemical Property of 1-BOC-4-AMINOINDOLE

Chemical Property:

• Vapor Pressure: 4.18E-06mmHg at 25°C
• Refractive Index: 1.571
• Boiling Point: 384.2 °C at 760 mmHg
• PKA: 4.18±0.10(Predicted)
• Flash Point: 186.1 °C
• PSA: 57.25000
• Density: 1.16 g/cm³
• LogP: 3.58790
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-aminoindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Boc-4-aminoindole is used as a reactant in the preparation of 7H-pyrrolo[2,3-H]quinazoline compounds as therapeutic mTOR kinase and PI3 kinase inhibitors.

Technology Process of 1-BOC-4-AMINOINDOLE

There total 4 articles about 1-BOC-4-AMINOINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 4-nitro-1H-indole-1-carboxylate (913836-24-5) → tert-butyl 4-amino-1H-indole-1-carboxylate (885270-30-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 8h; under 2585.81 Torr;

Reference yield: 94.0%

4-amino-1H-indole (5192-23-4) + tert-butyl 1H-imidazole-1-carboxylate (49761-82-2) → tert-butyl 4-amino-1H-indole-1-carboxylate (885270-30-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201203976

Reference yield: 88.0%

tert-butyl 4-nitro-1H-indole-1-carboxylate (913836-24-5) → tert-butyl 4-amino-1H-indole-1-carboxylate (885270-30-4) + C13H18N2O2 (885272-42-4)

Guidance literature:

With hydrogen; 5% Pd(II)/C(eggshell); In toluene; at 20 ℃; for 3h; under 2585.81 Torr;

upstream raw materials:

tert-butyl 4-nitro-1H-indole-1-carboxylate

4-amino-1H-indole

tert-butyl 1H-imidazole-1-carboxylate