5192-23-4 Usage
Chemical Properties
Greenish-grey to tan powder
Uses
Different sources of media describe the Uses of 5192-23-4 differently. You can refer to the following data:
1. Reactant for preparation of:? ;Inhibitors of bacterial thymidylate synthase1? ;Mimetics of non-alkaloid toxin lignan anticancer and antiviral agent Podophyllotoxin (PPT)2? ;Inhibitors of Gli1-mediated transcription in the Hedgehog pathway3? ;Protein kinase C θ (PKCθ) inhibitors4? ;Indolic non-peptidic HIV protease inhibitors5? ;Transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists6? ;Cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors7? ;11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibi
2. 4-Aminoindole may be used to synthesize:macrolactam tumour promoter indolactam Vtricyclic structure of 2-substituted-pyrrolo[2,3-h]quinolin-4-one4-azidoindole
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 5130, 1983 DOI: 10.1021/jo00173a071
General Description
4-Aminoindole is an indole derivative. Its cytokinin activity has been assessed by tobacco pith callus bioassay. 4-Aminoindole can be prepared by reacting 2,6-dinitrotoluene and N,N-dimethylformamide dimethylacetal in anhydrous DMF.
Check Digit Verification of cas no
The CAS Registry Mumber 5192-23-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,9 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5192-23:
(6*5)+(5*1)+(4*9)+(3*2)+(2*2)+(1*3)=84
84 % 10 = 4
So 5192-23-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5,10H,9H2
5192-23-4Relevant articles and documents
Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Application to Indole Synthesis
Maeda, Katsumi,Matsubara, Ryosuke,Hayashi, Masahiko
supporting information, p. 1530 - 1534 (2021/03/08)
The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system is reported. A simple combination of NH4OAc and K2CO3 under nonaerobic conditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.
