2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

Base Information

Chemical Name:2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol
CAS No.:1329669-77-3
Molecular Formula:C₂₅H₂₈ClN₇O
Molecular Weight:477.997
Hs Code.:

Synonyms:2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

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Chemical Property of 2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

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Technology Process of 2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

There total 4 articles about 2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1319068-87-5
2-[2-bromo-8-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

: 927983-28-6
1-(6-methylpyrimidin-4-yl)piperidin-4-amine

: 1329669-77-3
2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

Guidance literature:: With sodium phenoxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 160 ℃; for 15h; Sealed tube; Inert atmosphere;

Reference yield:

: N-(3-bromo-6-ethoxycarbonyl-pyridin-2-yl)-N'-ethoxycarbonyl-thiourea

: 1329669-77-3
2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 4 h / 20 °C / Inert atmosphere

2.1: toluene; tetrahydrofuran / 1 h / -40 - -30 °C

2.2: 20 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

3.2: 3 h / 60 - 75 °C / Inert atmosphere

4.1: sodium phenoxide / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 15 h / 160 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium phenoxide; sodium carbonate; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;

Reference yield:

: 1319068-81-9
2-amino-8-bromo-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid methyl ester

: 1329669-77-3
2-{8-(4-chloro-phenyl)-2-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene; tetrahydrofuran / 1 h / -40 - -30 °C

1.2: 20 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

2.2: 3 h / 60 - 75 °C / Inert atmosphere

3.1: sodium phenoxide / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 15 h / 160 °C / Inert atmosphere

With sodium phenoxide; sodium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; toluene;