Technology Process of (S)-3-methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid
There total 15 articles about (S)-3-methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-methyl 3-methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoate;
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 80 - 85 °C / Inert atmosphere
2: dibenzoyl peroxide / tetrachloromethane / 80 °C
3: triethylamine / toluene / Reflux
4: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux
5: pyridine / dichloromethane / 16 h
6: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C
With
pyridine; water; iron; sodium carbonate; ammonium chloride; triethylamine; lithium hydroxide; dibenzoyl peroxide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: bromine; iron / 16 h / 0 - 20 °C
2.1: thionyl chloride / 0 - 20 °C
3.1: potassium acetate; bis(pinacol)diborane / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere
3.2: 16 h / 80 °C / Inert atmosphere
4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C
5.1: triethylamine / toluene / Reflux
6.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 16 h / Reflux
7.1: pyridine / dichloromethane / 16 h
8.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C
With
pyridine; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); water; bromine; potassium acetate; iron; ammonium chloride; triethylamine; bis(pinacol)diborane; lithium hydroxide;
palladium diacetate;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
