N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-cyclohexyl thiosemicarbazide

Base Information

• Chemical Name: N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-cyclohexyl thiosemicarbazide
• CAS No.: 867154-24-3
• Molecular Formula: C₂₆H₂₉ClN₄O₃S
• Molecular Weight: 513.06
• Mol file: 867154-24-3.mol

Synonyms:N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-cyclohexyl thiosemicarbazide

Chemical Property of N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-cyclohexyl thiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-cyclohexyl thiosemicarbazide

There total 2 articles about N₁-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N₄-cyclohexyl thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

isothiocyanatocyclohexane (1122-82-3) + [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hydrazide (867154-15-2) → N1-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N4-cyclohexyl thiosemicarbazide (867154-24-3)

Guidance literature:

In ethanol; for 10h; Heating;

DOI:10.1002/ardp.200400891

Reference yield:

indomethacin ethyl ester (16401-99-3) → N1-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N4-cyclohexyl thiosemicarbazide (867154-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / hydrazine hydrate / ethanol / 30 h / Heating

2: 84 percent / ethanol / 10 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1002/ardp.200400891

Reference yield: 72.0%

N1-[2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-acetyl]-N4-cyclohexyl thiosemicarbazide (867154-24-3) → 5-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-ylmethyl]-4-cyclohexyl-3-mercapto-4H-1,2,4-triazole

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1002/ardp.200400891

upstream raw materials:

isothiocyanatocyclohexane

[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hydrazide

indomethacin ethyl ester