4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester

Base Information

• Chemical Name: 4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester
• CAS No.: 875433-16-2
• Molecular Formula: C₁₉H₁₈BrFO₃
• Molecular Weight: 393.253
• Mol file: 875433-16-2.mol

Synonyms:4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester

Chemical Property of 4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester

There total 1 articles about 4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-(4-bromophenyl)-3-(4-fluorophenyl)propan-1-one (875433-11-7) + ethyl bromoacetate (105-36-2) → 4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester (875433-16-2)

Guidance literature:

1-(4-bromophenyl)-3-(4-fluorophenyl)propan-1-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -60 ℃; for 1h;

ethyl bromoacetate; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/jm051101g

Reference yield:

4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester (875433-16-2) + phenylacetylene (536-74-3) → 3-(4-fluoro-benzyl)-4-oxo-4-(4-phenylethynyl-phenyl)-butyric acid ethyl ester

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 75 ℃;

DOI:10.1021/jm051101g

Reference yield:

4-(4-bromophenyl)-3-(4-fluorobenzyl)-4-oxobutyric acid ethyl ester (875433-16-2) → 3-(4-fluoro-benzyl)-4-oxo-4-(4-phenylethynyl-phenyl)-butyric acid

Guidance literature:

Multi-step reaction with 2 steps

1: PdCl₂(PPh₃)2; CuI; Et₃N / dimethylformamide / 75 °C

2: aq. NaOH / methanol / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; triethylamine; In methanol; N,N-dimethyl-formamide; 1: Sonogashira reaction;

DOI:10.1021/jm051101g

upstream raw materials:

1-(4-bromophenyl)-3-(4-fluorophenyl)propan-1-one

ethyl bromoacetate