2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

Base Information

Chemical Name:2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride
CAS No.:123579-66-8
Molecular Formula:C₁₉H₂₈N₂O*ClH
Molecular Weight:336.905
Hs Code.:

Synonyms:2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

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Chemical Property of 2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

Chemical Property:

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Technology Process of 2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

There total 3 articles about 2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 136053-68-4
2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride

: 109-76-2,54018-94-9
Trimethylenediamine

: 123579-66-8
2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

Guidance literature:: In chloroform; Ambient temperature;

Reference yield:

: 77-35-0
3-chloro-1-cyclohexyl-1-phenyl-propan-1-ol

: 123579-66-8
2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / dimethylsulfoxide / 3 h / 140 °C

2: 63 percent / 10percent HCl/Et₂O / tetrahydrofuran / 48 h

3: 59 percent / CHCl₃ / Ambient temperature

With hydrogenchloride; diethyl ether; In tetrahydrofuran; chloroform; dimethyl sulfoxide;

Reference yield:

: 123579-86-2
4-Phenyl-4-cyclohexyl-4-hydroxbutyronitrile

: 123579-66-8
2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / 10percent HCl/Et₂O / tetrahydrofuran / 48 h

2: 59 percent / CHCl₃ / Ambient temperature

With hydrogenchloride; diethyl ether; In tetrahydrofuran; chloroform;