2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride

Base Information

• Chemical Name: 2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride
• CAS No.: 136053-68-4
• Molecular Formula: C₁₆H₂₁NO*ClH
• Molecular Weight: 279.81
• Mol file: 136053-68-4.mol

Synonyms:2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride

Chemical Property of 2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride

There total 2 articles about 2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-Phenyl-4-cyclohexyl-4-hydroxbutyronitrile (123579-86-2) → 2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride (136053-68-4)

Guidance literature:

With hydrogenchloride; diethyl ether; In tetrahydrofuran; for 48h;

Reference yield:

3-chloro-1-cyclohexyl-1-phenyl-propan-1-ol (77-35-0) → 2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride (136053-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / dimethylsulfoxide / 3 h / 140 °C

2: 63 percent / 10percent HCl/Et₂O / tetrahydrofuran / 48 h

With hydrogenchloride; diethyl ether; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield: 59.0%

2-Imino-5-phenyl-5-cyclohexyltetrahydrofuran hydrochloride (136053-68-4) + Trimethylenediamine (109-76-2,54018-94-9) → 2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride (123579-66-8)

Guidance literature:

In chloroform; Ambient temperature;

upstream raw materials:

4-Phenyl-4-cyclohexyl-4-hydroxbutyronitrile

3-chloro-1-cyclohexyl-1-phenyl-propan-1-ol

Downstream raw materials:

2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-2-imidazoline hydrochloride

2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-4⁽⁵⁾-methyl-2-imidazoline hydrochloride

2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1,4,5,6-tetrahydropyrimidine hydrochloride

2-(3-Phenyl-3-cyclohexyl-3-hydroxy)propyl-1H-4,5,6,7-tetrahydrodiazepine hydrochloride