4-Bromo-α-(fluoromethyl)benzenemethanamine

Base Information

• Chemical Name: 4-Bromo-α-(fluoromethyl)benzenemethanamine
• CAS No.: 1246567-29-2
• Molecular Formula: C₈H₉BrFN
• Molecular Weight: 218.069
• Mol file: 1246567-29-2.mol

Synonyms:(±)-1-(4-bromophenyl)-2-fluoro-ethanamine

Chemical Property of 4-Bromo-α-(fluoromethyl)benzenemethanamine

Chemical Property:

• Melting Point: 214-230°C
• Refractive Index: n20/D1.560
• Density: 1.494 g/mL at 25 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-α-(fluoromethyl)benzylamine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 4-Bromo-α-(fluoromethyl)benzenemethanamine

There total 3 articles about 4-Bromo-α-(fluoromethyl)benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H7BrFN → (±)-1-(4-bromophenyl)-2-fluoro-ethanamine (1246567-29-2)

Guidance literature:

C₈H₇BrFN; With sodium tetrahydroborate; In ethanol; at 20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In ethanol; water;

With sodium hydroxide; In ethanol; water;

DOI:10.1016/j.tet.2010.06.081

Reference yield:

1-(4-bromophenyl)-2-fluoroethan-1-one (403-30-5) → (±)-1-(4-bromophenyl)-2-fluoro-ethanamine (1246567-29-2)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol; at 20 ℃; for 24h;

DOI:10.1002/anie.201510554

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) → (±)-1-(4-bromophenyl)-2-fluoro-ethanamine (1246567-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride; zinc(II) fluoride / acetonitrile / 24 h / 100 °C

2: ammonium acetate; sodium cyanoborohydride / methanol / 24 h / 20 °C

With potassium fluoride; zinc(II) fluoride; ammonium acetate; sodium cyanoborohydride; In methanol; acetonitrile;

DOI:10.1002/anie.201510554

upstream raw materials:

para-bromophenacyl bromide

1-(4-bromophenyl)-2-fluoroethan-1-one

Downstream raw materials:

(R)-1-(4-bromophenyl)-2-fluoroethylamine

(S)-N-(1-(4-bromophenyl)-2-fluoroethyl)-2-methoxyacetamide

(S)-1-(4-bromophenyl)-2-fluoroethylamine

para-bromoacetophenone

Refernces

• 1、 Thvedt, Thor Hkon Krane,Fuglseth, Erik,Sundby, Eirik,Hoff, Brd Helge. "Enantioenriched 1-aryl-2-fluoroethylamines. Efficient lipase-catalysed resolution and limitations to the Mitsunobu inversion protocol". experimental part. p. 6733 - 6743. Retrieved 2010/09/30.