403-30-5

Basic information

• Product Name: Ethanone, 1-(4-bromophenyl)-2-fluoro- (9CI)
• Synonyms: Ethanone, 1-(4-bromophenyl)-2-fluoro- (9CI);1-(4-bromophenyl)-2-fluoroethanone;2-fluoro-1-(4-bromophenyl) ethanone（WS203224）
• CAS NO: 403-30-5
• Molecular Formula: C₈H₆BrFO
• Molecular Weight: 217.0350432
• Product Categories: ACETYLHALIDE
• Mol File: 403-30-5.mol
• Article Data: 18

Chemical Properties

• Melting Point: 72 °C
• Boiling Point: 282.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.521±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 1-(4-bromophenyl)-2-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-bromophenyl)-2-fluoro- (9CI)(403-30-5)
• EPA Substance Registry System: Ethanone, 1-(4-bromophenyl)-2-fluoro- (9CI)(403-30-5)

Safety Data

• Hazardous Substances Data: 403-30-5(Hazardous Substances Data)

Upstream product

• 78904-87-7 (1-(4-bromophenyl)ethylidene)hydrazine 
• 26510-95-2 ethyl 4-Bromobenzoylacetate 
• 373-53-5 fluoroiodomethane 
• 192436-83-2 4-bromo-N-methoxy-N-methylbenzamide 
• 64929-35-7 3-(4-bromophenyl)-3-oxopropanoic acid 
• 89108-50-9 1-(1-azidovinyl)-4-bromobenzene 
• 1374152-33-6 1-(1-azido-2-iodoethyl)-4-bromobenzene 
• 364340-35-2 STK₀₈₈₀₄₅ 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 99-90-1 para-bromoacetophenone 
• 1046785-17-4 1-bromo-4-(2-fluoro-1,1-dimethoxyethyl)benzene 
• 67-56-1 methanol 
• 586-75-4 4-chlorobenzoyl chloride 
• 888476-00-4 2,2-dichloro-2-fluoro-1-(4-bromophenyl)ethanol 

Downstream Products

• 99-90-1 para-bromoacetophenone 
• 156335-24-9 (+/-)-1-(4-bromophenyl)-2-fluoroethanol 
• 7604-31-1 1-(4-bromo-phenyl)-2-fluoro-ethanone-(2,4-dinitro-phenylhydrazone) 
• 201206-41-9 2-bromo-1-(4-bromophenyl)-2-fluoroethan-1-one 
• 343564-26-1 1-(4-bromophenyl)-2,4,4,4-tetrafluoro-1,3-butanedione 
• 1246567-42-9 (S)-1-(4-bromophenyl)-2-fluoroethylamine 
• 1246567-36-1 (R)-1-(4-bromophenyl)-2-fluoroethylamine 
• 1246567-29-2 (±)-1-(4-bromophenyl)-2-fluoro-ethanamine 

Relevant articles and documents

Method for synthesizing alpha-fluorinated ketone through hydrazone aliphatic chain monoketone

The invention belongs to the technical field of organic synthesis, and provides a method for synthesizing alpha-ketone fluoride through hydrazone aliphatic chain monoketone, which comprises the following steps of: reacting aliphatic chain monoketone with hydrazine hydrate to obtain hydrazone, and reacting hydrazone with a compound represented by formula 2 under a heating condition to complete hydrazone defluorination. The fluorinated product is widely applied to medicines, the reaction conditions are mild, and the process is simple.

Double Enzyme-Catalyzed One-Pot Synthesis of Enantiocomplementary Vicinal Fluoro Alcohols

A double-enzyme-catalyzed strategy for the synthesis of enantiocomplementary vicinal fluoro alcohols through a one-pot, three-step process including lipase-catalyzed hydrolysis, spontaneous decarboxylative fluorination, and subsequent ketoreductase-catalyzed reduction was developed. With this approach, β-ketonic esters were converted to the corresponding vicinal fluoro alcohols with high isolated yields (up to 92percent) and stereoselectivities (up to 99percent). This new cascade process addresses some issues in comparison with traditional methods such as environmentally hazardous reaction conditions and low stereoselectivity outcome.

Decarboxylative fluorination of β-Ketoacids with N-fluorobenzenesulfonimide (NFSI) for the synthesis of α-fluoroketones: Substrate scope and mechanistic investigation

Cesium carbonate (Cs2CO3)-mediated decarboxylative fluorination of β-ketoacids using NFSI in the MeCN/H2O mixed solvent system affords α-fluoroketones with a broad scope. Both electron-rich and electron-deficient α-non-substituted β-ketoacids are amenable to this protocol. The mechanistic study indicates that the reaction proceeds through electrophilic fluorination followed by decarboxylation, which is different from the decarboxylative fluorination of normal carboxylic acids.