5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one

Base Information

• Chemical Name: 5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one
• CAS No.: 252875-48-2
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.276
• Mol file: 252875-48-2.mol

Synonyms:5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one

Chemical Property of 5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one

There total 2 articles about 5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

cycl-isopropylidene malonate (2033-24-1) + 3-nitro-benzaldehyde (99-61-6) + acetylacetone (123-54-6,81235-32-7) → 5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one (252875-48-2)

Guidance literature:

With ammonium acetate; In acetic acid; for 10h; Heating;

DOI:10.1002/1099-0690(200006)2000:11<2079::AID-EJOC2079>3.0.CO;2-#

Reference yield: 42.0%

ammonium acetate (631-61-8,92206-38-7) + 3-nitro-benzaldehyde (99-61-6) + acetylacetone (123-54-6,81235-32-7) → 5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one (252875-48-2)

Guidance literature:

ammonium acetate; acetylacetone; With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 80 ℃; for 1h;

3-nitro-benzaldehyde; With cycl-isopropylidene malonate; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 80 ℃; for 3h;

DOI:10.1002/hc.20221

Reference yield: 63.0%

5-acetyl-6-methyl-4-(3'-nitrophenyl)-3,4-dihydropyridin-2(1H)-one (252875-48-2) → 3a,4,5,7a-tetrahydro-3,7a-dimethyl-4-(3'-nitrophenyl)isoxazolo[5,4-b]pyridin-6(7H)-one

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 48h; Heating;

DOI:10.1002/1099-0690(200006)2000:11<2079::AID-EJOC2079>3.0.CO;2-#

upstream raw materials:

cycl-isopropylidene malonate

3-nitro-benzaldehyde

acetylacetone

ammonium acetate