phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate

Base Information

• Chemical Name: phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate
• CAS No.: 884340-27-6
• Molecular Formula: C₁₅H₁₁ClF₃NO₃
• Molecular Weight: 345.705
• Mol file: 884340-27-6.mol

Synonyms:phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate

Chemical Property of phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate

Chemical Property:

Purity/Quality:

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Technology Process of phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate

There total 2 articles about phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chloro-2-methoxy-5-(trifluoromethyl)phenylaniline (284462-45-9) + phenyl chloroformate (1885-14-9) → phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate (884340-27-6)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 1.58333h; Inert atmosphere;

DOI:10.1021/jm801509w

Reference yield: 100.0%

→ phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate (884340-27-6)

Guidance literature:

Reference yield: 92.0%

7-(4-aminophenoxy)-1,3-dihydroimidazole[4,5-b]pyridine-2-one (884339-96-2) + phenyl 4-chloro-2-methoxy-5-(trifluoromethyl)phenylcarbamate (884340-27-6) → 1-(4-chloro-2-methoxy-5-(trifluoromethyl)phenyl)-3-(4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:

In dimethyl sulfoxide; at 85 ℃; for 2h;

DOI:10.1021/jm801509w

upstream raw materials:

4-chloro-2-methoxy-5-(trifluoromethyl)phenylaniline

phenyl chloroformate