3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride

Base Information

Chemical Name:3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride
CAS No.:1433379-78-2
Molecular Formula:C₁₇H₁₅ClFNO₃*ClH
Molecular Weight:372.223
Hs Code.:

Synonyms:3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride

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Chemical Property of 3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride

Chemical Property:

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Technology Process of 3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride

There total 5 articles about 3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1433404-25-1
3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester

: 1433379-78-2
3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 18h;

Reference yield:

: 1433405-92-5
(R)-1-(4-chloro-2-fluorophenyl)propylamine L-aspartate

: 1433379-78-2
3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Large scale

1.2: 20 °C / Large scale

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 0.67 h / -78 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h

With hydrogenchloride; n-butyllithium; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;

Reference yield:

: 61072-56-8
4-chloro-2-fluorobenzaldehyde

: 1433379-78-2
3-[3-((R)-1-aminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) tetraethanolate / dichloromethane / 20 °C / Large scale

1.2: 1 h / Large scale

2.1: tetrahydrofuran; diethyl ether / 3 h / -78 - -70 °C / Inert atmosphere; Large scale

2.2: 1.33 h / 20 °C / Inert atmosphere; Large scale

2.3: Heating; Large scale

3.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Large scale

3.2: 20 °C / Large scale

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

4.2: 0.67 h / -78 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane;