3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester

Base Information

Chemical Name:3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester
CAS No.:1433404-25-1
Molecular Formula:C₂₆H₃₁ClFNO₅
Molecular Weight:491.987
Hs Code.:

Synonyms:3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester

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Chemical Property of 3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester

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Technology Process of 3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester

There total 5 articles about 3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1097776-71-0
isophthalic acid 1-tert-butyl ester 3-methyl ester

: 1433401-71-8
[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1433404-25-1
3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester

Guidance literature:: [(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

isophthalic acid 1-tert-butyl ester 3-methyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1433404-25-1
3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 0.67 h / -78 °C

With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

: 1433405-92-5
(R)-1-(4-chloro-2-fluorophenyl)propylamine L-aspartate

: 1433404-25-1
3-[3-((R)-1-tert-butoxycarbonylaminopropyl)-6-chloro-2-fluorobenzoyl]benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Large scale

1.2: 20 °C / Large scale

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 0.67 h / -78 °C

With n-butyllithium; sodium hydroxide; In tetrahydrofuran; hexane;