tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate

Base Information

Chemical Name:tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate
CAS No.:1431568-41-0
Molecular Formula:C₂₈H₃₅NO₃
Molecular Weight:433.591
Hs Code.:

Synonyms:tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate

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Chemical Property of tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate

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Technology Process of tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate

There total 6 articles about tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1431568-40-9
tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate

: 7103-09-5
4-but-1-enylmagnesium bromide

: 1431568-41-0
tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1431568-39-6
(1R,3S)-3-((biphenyl-4-ylmethyl)(tert-butoxycarbonyl)amino)cyclopentane carboxylic acid

: 1431568-41-0
tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 71830-08-5
(1R,3S)-3-aminocyclopentanecarboxylic acid

: 1431568-41-0
tert-butyl ([1,1'-biphenyl]-4-ylmethyl)((1S,3R)-3-(pent-4-enoyl)cyclopentyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / methanol / 1 h

2: sodium tris(acetoxy)borohydride / methanol / 4.17 h / 20 °C

3: sodium hydrogencarbonate / ethyl acetate; water / 20 °C

4: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;