tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate

Base Information

Chemical Name:tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate
CAS No.:1431568-40-9
Molecular Formula:C₂₆H₃₄N₂O₄
Molecular Weight:438.567
Hs Code.:

Synonyms:tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate

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Chemical Property of tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate

Chemical Property:

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Technology Process of tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate

There total 5 articles about tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1431568-39-6
(1R,3S)-3-((biphenyl-4-ylmethyl)(tert-butoxycarbonyl)amino)cyclopentane carboxylic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1431568-40-9
tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 71830-08-5
(1R,3S)-3-aminocyclopentanecarboxylic acid

: 1431568-40-9
tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / methanol / 1 h

2: sodium tris(acetoxy)borohydride / methanol / 4.17 h / 20 °C

3: sodium hydrogencarbonate / ethyl acetate; water / 20 °C

4: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 1431568-38-5
(1R,3S)-3-(biphenyl-4-ylmethylamino)cyclopentanecarboxylic acid

: 1431568-40-9
tert-butyl-[1,1'-biphenyl]-4-ylmethyl-{(1S,3R)-3-(methoxy(methyl)carbamoyl)-cyclopentyl}-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethyl acetate; water / 20 °C

2: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; ethyl acetate;