4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride

Base Information

Chemical Name:4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride
CAS No.:1613398-14-3
Molecular Formula:C₂₄H₂₂N₂O₃*ClH
Molecular Weight:422.911
Hs Code.:

Synonyms:4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride

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Chemical Property of 4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride

Chemical Property:

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Technology Process of 4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride

There total 8 articles about 4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1613399-49-7
4-(benzyloxy)-1-(1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one

: 1613398-14-3
4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride

Guidance literature:

Reference yield:

: 1073-06-9
3-fluorobromobenzene

: 1613398-14-3
4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 80 °C / Inert atmosphere

2.1: water; perchloric acid / 1,4-dioxane / 2 h / 20 °C

3.1: hydrogenchloride / isopropyl alcohol / Reflux

4.1: dichloromethane / 20 °C

5.1: caesium carbonate / toluene / 0.25 h / 20 °C / Inert atmosphere

5.2: 24 h / Inert atmosphere; Sealed tube; Reflux

6.1: hydrogenchloride / ethyl acetate; methanol / 1 h / 20 °C

7.1: acetic acid; sodium tris(acetoxy)borohydride / methanol / 1 h / 20 °C

7.2: 20 °C

7.3: 0.5 h / 20 °C

With hydrogenchloride; perchloric acid; potassium tert-butylate; water; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1002/cmdc.202100707

Reference yield:

: 53937-02-3
4-(benzyloxy)pyridin-2(1H)-one

: 1613398-14-3
4-(Benzyloxy)-1-(2-methyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-7-yl)pyridin-2(1H)-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / toluene / 0.25 h / 20 °C / Inert atmosphere

1.2: 24 h / Inert atmosphere; Sealed tube; Reflux

2.1: hydrogenchloride / ethyl acetate; methanol / 1 h / 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / methanol / 1 h / 20 °C

3.2: 20 °C

3.3: 0.5 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; In methanol; ethyl acetate; toluene;
DOI:10.1002/cmdc.202100707