Didesmethylsibutramine

Base Information

Chemical Name:Didesmethylsibutramine
CAS No.:84467-54-9
Molecular Formula:C₁₅H₂₂ClN
Molecular Weight:251.799
Hs Code.:
European Community (EC) Number:617-571-2
UNII:987R943R3P
DSSTox Substance ID:DTXSID801004734
Nikkaji Number:J553.373B
Wikipedia:Didesmethylsibutramine
Wikidata:Q27272099
ChEMBL ID:CHEMBL1625728
Mol file:84467-54-9.mol

Synonyms:(R)-DDMS;BTS 54 524;BTS 54524;BTS-54524;di-desmethylsibutramine;didesmethylsibutramine;Meridia;mono-desmethylsibutramine;N-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCl;Reductil;sibutramine;sibutramine hydrochloride

Suppliers and Price of Didesmethylsibutramine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Didesmethyl Sibutramine
5mg
$ 446.00

TRC
DidesmethylSibutramine
2mg
$ 120.00

Crysdot
1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine 95+%
1g
$ 880.00

Chemenu
1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine 95%
1g
$ 830.00

Biosynth Carbosynth
Didesmethyl sibutramine
5 mg
$ 280.00

Biosynth Carbosynth
Didesmethyl sibutramine
2 mg
$ 180.00

Biosynth Carbosynth
Didesmethyl sibutramine
1 mg
$ 115.00

Biosynth Carbosynth
Didesmethyl sibutramine
500 ug
$ 75.00

Biosynth Carbosynth
Didesmethyl sibutramine
10 mg
$ 475.00

American Custom Chemicals Corporation
DIDESMETHYL SIBUTRAMINE 95.00%
5MG
$ 455.32

Total 24 raw suppliers

Chemical Property of Didesmethylsibutramine

Chemical Property:

Vapor Pressure:0.000102mmHg at 25°C
Boiling Point:337.9°C at 760 mmHg
PKA:10.82±0.42(Predicted)
Flash Point:195.1°C
PSA：26.02000
Density:1.072g/cm³
LogP:4.83540
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:251.1440774
Heavy Atom Count:17
Complexity:239

Purity/Quality:

97% ^*data from raw suppliers

Didesmethyl Sibutramine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N
Uses A metabolite of Sibutramine, a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure A metabolite of Sibutramine, a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.

Technology Process of Didesmethylsibutramine

There total 68 articles about Didesmethylsibutramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: C₁₅H₁₉ClN^(1-)*Cl^(1-)*Mg⁽²⁺⁾

: 106650-56-0,84467-54-9
didesmethylsibutramine

Guidance literature:: With borane-THF; benzene-1,2-dicarboxylic acid; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4039(02)01905-6

Reference yield: 96.0%

: 84467-85-6
N-{1-[1-(4-chlorophenylcyclobutyl)]-3-methylbuty}formamide

: 106650-56-0,84467-54-9
didesmethylsibutramine

Guidance literature:: With hydrogenchloride; In various solvent(s); for 18h; Heating;
DOI:10.1039/p19960002583

Reference yield: 95.0%

: C₃₂H₃₉ClN₂O₄S₂

: 229639-56-9,84467-54-9
(R)-N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}amine

: 229639-57-0,84467-54-9
(S)-(-)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine

Guidance literature:: C₃₂H₃₉ClN₂O₄S₂; With sodium tetrahydroborate; titanium(IV) tetraethanolate; In tetrahydrofuran; at -15 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol;

With sodium hydroxide; In tetrahydrofuran; methanol; Product distribution / selectivity;