3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile

Base Information

Chemical Name:3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile
CAS No.:147766-02-7
Molecular Formula:C₂₀H₂₁Cl₂N₃O₂Si
Molecular Weight:434.397
Hs Code.:

Synonyms:3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile

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Chemical Property of 3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile

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Technology Process of 3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile

There total 6 articles about 3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 7677-24-9
trimethylsilyl cyanide

: 147766-01-6
3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolineacetaldehyde

: 147766-02-7
3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile

Guidance literature:: With zinc(II) iodide; at 25 ℃; for 18h;
DOI:10.1016/0223-5234(92)90112-E

Reference yield:

1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one: 52099-72-6
1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one

: 147766-02-7
3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, 2) KI, 3.) aq. H₂SO₄

2: 1.) NaH / 1.) DMF, 25 min, 2.) DMF, a) 25 deg C, 24 h, 2.) 100-115 deg C, 18 h

3: 3 N aq. HCl / dioxane / 0.67 h / 100 °C

4: 91 percent / zinc iodide / 18 h / 25 °C

With hydrogenchloride; sulfuric acid; sodium hydride; potassium iodide; zinc(II) iodide; In 1,4-dioxane;
DOI:10.1016/0223-5234(92)90112-E

Reference yield:

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 147766-02-7
3-(3-(3,4-dichlorobenzyl)-2-oxo-1-benzimidazolinyl)-2-(trimethylsilyloxy)propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, 2) KI, 3.) aq. H₂SO₄

2: 1.) NaH / 1.) DMF, 25 min, 2.) DMF, a) 25 deg C, 24 h, 2.) 100-115 deg C, 18 h

3: 3 N aq. HCl / dioxane / 0.67 h / 100 °C

4: 91 percent / zinc iodide / 18 h / 25 °C

With hydrogenchloride; sulfuric acid; sodium hydride; potassium iodide; zinc(II) iodide; In 1,4-dioxane;
DOI:10.1016/0223-5234(92)90112-E