β-Benzoylisonicotinic acid

Base Information

• Chemical Name: β-Benzoylisonicotinic acid
• CAS No.: 74975-28-3
• Molecular Formula: C₁₃H₉NO₃
• Molecular Weight: 227.219
• Mol file: 74975-28-3.mol

Synonyms:β-Benzoylisonicotinic acid

Chemical Property of β-Benzoylisonicotinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of β-Benzoylisonicotinic acid

There total 9 articles about β-Benzoylisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-Hydroxy-2-methyl-3-phenyl-pyrro<3,4-c>pyridine-1(3H)-one (133030-38-3) → β-Benzoylisonicotinic acid (74975-28-3)

Guidance literature:

With sulfuric acid; for 0.75h; Heating;

DOI:10.1007/BF00808955

Reference yield: 92.0%

3-Hydroxy-2,3-diphenyl-2,3-dihydro-pyrrolo[3,4-c]pyridin-1-one (133030-39-4) → β-Benzoylisonicotinic acid (74975-28-3)

Guidance literature:

With sulfuric acid; for 0.75h; Heating;

DOI:10.1007/BF00808955

Reference yield: 39.0%

cinchomeronic anhydride (4664-08-8) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → β-Benzoylisonicotinic acid (74975-28-3) + 4-benzoylpyridine-3-carboxylic acid (74975-25-0)

Guidance literature:

With aluminium trichloride; at 100 - 105 ℃; for 8h;

DOI:10.1007/BF00552781

upstream raw materials:

cinchomeronic anhydride

benzene

3-Hydroxy-2-methyl-3-phenyl-pyrro<3,4-c>pyridine-1(3H)-one

3-Hydroxy-2,3-diphenyl-2,3-dihydro-pyrrolo[3,4-c]pyridin-1-one

Downstream raw materials:

3-Benzoylpyridine

2-benzyl-3-hydroxy-3-phenyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one

N-tert-butyl-4-benzoylisonicotinamide

benz[g]isoquinoline-5,10-dione

Refernces

• 1、 Epsztajn, Jan,Jozwiak, Andrzej,Czech, Krzysztof,Szczesniak, Aleksandra K.. "Application of Organolithium and Related Reagents in Synthesis, Part VI . A General Study of the Lithiation of Secondary Picoline- and Isonicotine Amides". . p. 909 - 921. Retrieved 2007/10/02.