N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide

Base Information

Chemical Name:N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide
CAS No.:1378384-15-6
Molecular Formula:C₂₇H₃₁F₃N₄
Molecular Weight:468.565
Hs Code.:

Synonyms:N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide

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Chemical Property of N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide

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Technology Process of N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide

There total 4 articles about N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 7677-24-9
trimethylsilyl cyanide

: 1378384-05-4
N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbothioamide

: 1378384-15-6
N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide

Guidance literature:: N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbothioamide; With sodium hydride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

With methyl iodide; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

trimethylsilyl cyanide; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201200523

Reference yield:

: 622-78-6
Benzyl isothiocyanate

: 1378384-15-6
N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: lithium triethylborohydride / tetrahydrofuran; toluene / 0.5 h / -70 °C / Inert atmosphere

2.2: 2 h / -70 - 20 °C / Inert atmosphere

3.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 15 h / -30 °C / Inert atmosphere

4.1: sodium hydride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 0 °C / Inert atmosphere

4.3: 2 h / 20 °C / Inert atmosphere

With sodium hydride; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.201200523

Reference yield:

: 1378383-46-0
N-benzyl-2,3-dihydro-1H-pyrrole-1-carbothioamide

: 1378384-15-6
N-benzyl-4-hexyl-8-(trifluoromethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1-carbimidoyl cyanide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / -30 °C / Inert atmosphere

2.1: sodium hydride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

2.3: 2 h / 20 °C / Inert atmosphere

With sodium hydride; In dichloromethane;
DOI:10.1002/chem.201200523