1-[Bis(4-methoxyphenyl)phenylmethyl]azetidine

Base Information

Chemical Name:1-[Bis(4-methoxyphenyl)phenylmethyl]azetidine
CAS No.:153652-92-7
Molecular Formula:C₂₄H₂₅NO₂
Molecular Weight:359.468
Hs Code.:
DSSTox Substance ID:DTXSID001250379

Synonyms:DTXSID001250379;1-[Bis(4-methoxyphenyl)phenylmethyl]azetidine;153652-92-7

Suppliers and Price of 1-[Bis(4-methoxyphenyl)phenylmethyl]azetidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[Bis(4-methoxyphenyl)phenylmethyl]azetidine

Chemical Property:

XLogP3:5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:359.188529040
Heavy Atom Count:27
Complexity:417

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)N4CCC4

Technology Process of 1-[Bis(4-methoxyphenyl)phenylmethyl]azetidine

There total 3 articles about 1-[Bis(4-methoxyphenyl)phenylmethyl]azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 153652-94-9
3-chloro-N-4,4'-dimethoxytritylpropanamine

: 153652-92-7
N-4,4'-dimethoxytritylazetidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 20h;
DOI:10.1002/jhet.5570300506

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 153652-92-7
N-4,4'-dimethoxytritylazetidine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / triethylamine / CH₂Cl₂ / 3 h / 0 °C

2: 91 percent / anhyd. potassium carbonate / dimethylformamide / 20 h / 130 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570300506

Reference yield:

: 40615-35-8
4,4'-dimethoxytrityl alcohol

: 153652-92-7
N-4,4'-dimethoxytritylazetidine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / thionyl chloride / heptane / 1.) 0 deg C, 10 min, 2.) RT, 10 min, 3.) reflux, 1 h

2: 96 percent / triethylamine / CH₂Cl₂ / 3 h / 0 °C

3: 91 percent / anhyd. potassium carbonate / dimethylformamide / 20 h / 130 °C

With thionyl chloride; potassium carbonate; triethylamine; In n-heptane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570300506