4,4'-Dimethoxytrityl alcohol

Base Information

• Chemical Name: 4,4'-Dimethoxytrityl alcohol
• CAS No.: 40615-35-8
• Molecular Formula: C21H20 O3
• Molecular Weight: 320.388
• Hs Code.: 2909499000
• European Community (EC) Number: 255-001-0
• DSSTox Substance ID: DTXSID90193617
• Nikkaji Number: J294.716A
• Wikidata: Q83066368
• Mol file: 40615-35-8.mol

Synonyms:4,4'-Dimethoxytrityl alcohol;40615-35-8;bis(4-methoxyphenyl)-phenylmethanol;Bis(4-methoxyphenyl)(phenyl)methanol;4,4'-dimethoxytritanol;EINECS 255-001-0;Benzenemethanol, 4-methoxy-alpha-(4-methoxyphenyl)-alpha-phenyl-;Di[4-methoxyphenyl]-phenylmethanol;SCHEMBL29205;DTXSID90193617;Bis(4-methoxyphenyl)phenylmethanol;MFCD15530097;AKOS037645255;Bis(4-methoxyphenyl)(phenyl)methanol #;AS-59297;E77680;Benzenemethanol, 4-methoxy-.alpha.-(4-methoxyphenyl)-.alpha.-phenyl-

Chemical Property of 4,4'-Dimethoxytrityl alcohol

Chemical Property:

• Boiling Point: 488°Cat760mmHg
• PKA: 12.87±0.29(Predicted)
• Flash Point: 248.9°C
• PSA: 38.69000
• Density: 1.151g/cm³
• LogP: 3.98800
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 320.14124450
• Heavy Atom Count: 24
• Complexity: 337

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)O
• Uses: p,p''-Dimethoxytriphenylcarbinol, can be used in Amberlyst-15 catalyzed regioselective tritylation of sugar-based diols.

Technology Process of 4,4'-Dimethoxytrityl alcohol

There total 45 articles about 4,4'-Dimethoxytrityl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4'-dimethoxytrityl chloride (40615-36-9) → 4,4'-dimethoxytrityl alcohol (40615-35-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 0.5h; Ambient temperature;

Reference yield: 95.0%

methoxybenzene (100-66-3) + Benzoylformic acid (611-73-4) → 4,4'-dimethoxytrityl alcohol (40615-35-8)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 20 ℃; for 24h;

DOI:10.1021/jo990524l

Reference yield: 94.0%

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 4,4'-dimethoxytrityl alcohol (40615-35-8)

Guidance literature:

With tris(pentafluorophenyl)borate; In acetonitrile; at 20 ℃;

DOI:10.1002/anie.201600305

upstream raw materials:

4-Methoxybenzophenone

4-chloromethoxybenzene

(4-methoxyphenyl)magnesium iodide

4,4'-dimethoxytrityl chloride

Downstream raw materials:

4,4'-dimethoxytriphenylmethane

4,4'-dimethoxytrityl chloride

Hydroxy-phenyl-bis-(4-hydroxy-phenyl)-methan

(R)-2-Amino-3-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanyl]-propionic acid

Refernces

• 1、 -. "Efficient separation and purification method of 4,4'-dimethoxytrityl chloride and 4,4'-dimethoxytrityl alcohol". Paragraph 0026-0027; 0029-0030; 0032-0042. . Retrieved 2021/03/03.
• 2、 Corbin, Joshua R.,Fernández, Israel,Ketelboeter, Devin R.,Schomaker, Jennifer M.. "Biomimetic 2-Imino-Nazarov Cyclizations via Eneallene Aziridination". supporting information. p. 5568 - 5573. Retrieved 2020/04/09.