1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate
CAS No.:1284249-99-5
Molecular Formula:C₁₆H₂₁FN₂O₄
Molecular Weight:324.352
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate

There total 1 articles about 1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 458-50-4
1-bromo-2-fluoro-4-methoxybenzene

: 76003-29-7
4-(t-butyloxycarbonyl)piperazin-2-one

: 1284249-99-5
1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate

Guidance literature:: With potassium carbonate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; In 1,4-dioxane; at 120 ℃; for 84h;

Reference yield: 100.0%

: 1284249-99-5
1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate

: 1284250-00-5
1-[2-fluoro-4-(methyloxy)phenyl]-2-piperazinone hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 1.5h;

Reference yield:

: 1284249-99-5
1,1-dimethylethyl 4-[2-fluoro-4-(methyloxy)phenyl]-3-oxo-1-piperazinecarboxylate

: 1297141-46-8
4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-piperazinon

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h

2.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 1.25 h / 0 °C

3.1: boron tribromide / dichloromethane / 4 h / -78 °C / Cooling with ice bath

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 8.5 h / 100 °C

5.2: 0.17 h / 120 °C / microwave

With hydrogenchloride; potassium acetate; boron tribromide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;