2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1201645-14-8
Molecular Formula:C₃₂H₂₂N₄O
Molecular Weight:478.553
Hs Code.:

Synonyms:2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

There total 14 articles about 2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₂₄N₄O₂

: 1201645-14-8
2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With potassium carbonate; In ethanol; Reflux;

Reference yield:

: 4-(1-cyano-1-methylethyl)benzoic acid chloride

: 1201645-14-8
2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 12 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

4.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

5.1: hydrogenchloride / acetone / 24 h

6.1: hydrogenchloride / water / 24 h

7.1: potassium acetate / ethanol / 5 h / Reflux

8.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 12 h / Inert atmosphere; Reflux

10.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 1 h

11.1: tert.-butylnitrite; potassium acetate / toluene / 12 h / 60 °C

12.1: potassium carbonate / ethanol / Reflux

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; tert.-butylnitrite; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; caesium carbonate; ozone; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 9.1: Suzuki Coupling;

Reference yield:

: 129488-74-0
4-(1-cyano-1-methylethyl)benzoic acid

: 1201645-14-8
2-(4-(8-(1H-indazol-6-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 13 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

2.2: 25 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 12 h / Inert atmosphere; Reflux

11.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 1 h

12.1: tert.-butylnitrite; potassium acetate / toluene / 12 h / 60 °C

13.1: potassium carbonate / ethanol / Reflux

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; tert.-butylnitrite; oxalyl dichloride; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; caesium carbonate; ozone; N,N-dimethyl-formamide; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 10.1: Suzuki Coupling;