3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

Base Information

Chemical Name:3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione
CAS No.:732298-24-7
Molecular Formula:C₂₂H₂₃NO₄
Molecular Weight:365.429
Hs Code.:

3-benzo[1,3]dioxol-5-ylmethyl-1-(2-<i>tert</i>-butyl-phenyl)-pyrrolidine-2,5-dione

Synonyms:3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

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Chemical Property of 3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

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Technology Process of 3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

There total 1 articles about 3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 2606-51-1
3,4-Methylenedioxybenzyl bromide

: 210426-64-5
1-(2-tert-butylphenyl)-pyrrolidine-2,5-dione

: 732298-24-7
3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

: 3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

: (3S,4S)-3,4-Bis-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

Guidance literature:: 1-(2-tert-butylphenyl)-pyrrolidine-2,5-dione; With chiral PhCHMeNLiCHPhCHPhNHCHMePh; In tetrahydrofuran; at -78 ℃; for 1h;

3,4-Methylenedioxybenzyl bromide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; at -78 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1039/b403193h

Reference yield:

: 732298-24-7
3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

: 4-benzo[1,3]dioxol-5-yl-2-benzo[1,3]dioxol-5-ylmethyl-N-(2-tert-butyl-phenyl)-3-hydroxymethyl-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA; LiCl / tetrahydrofuran

1.2: DMPU / tetrahydrofuran

2.1: aq. NaBH₄ / propan-2-ol; toluene

With sodium tetrahydroborate; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; isopropyl alcohol; toluene;
DOI:10.1039/b403193h

Reference yield:

: 732298-24-7
3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

: 2606-51-1
3,4-Methylenedioxybenzyl bromide

: (3R,4R)-3,4-Bis-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione

Guidance literature:: 3-benzo[1,3]dioxol-5-ylmethyl-1-(2-tert-butyl-phenyl)-pyrrolidine-2,5-dione; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;

3,4-Methylenedioxybenzyl bromide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran;
DOI:10.1039/b403193h